TY - JOUR
T1 - Carbohydrate responsive element-binding protein (ChREBP)
T2 - A key regulator of glucose metabolism and fat storage
AU - Uyeda, Kosaku
AU - Yamashita, Hiromi
AU - Kawaguchi, Takumi
PY - 2002/6/15
Y1 - 2002/6/15
N2 - Feeding a high carbohydrate diet induces transcription of more than 15 genes involved in the metabolic conversion of glucose to fat. A new transcription factor binding to a glucose response element of the pyruvate kinase and lipogenesis enzyme genes was discovered recently. This factor, termed carbohydrate responsive element-binding protein (ChREBP), is activated in response to high glucose and up-regulates these genes. Cyclic AMP and a high fat diet inhibit ChREBP and slow down glucose utilization. ChREBP is able to control transcription of lipogenic enzyme genes in response to nutritional and hormonal inputs, and may play an important role in disease states such as diabetes, obesity, and hypertension.
AB - Feeding a high carbohydrate diet induces transcription of more than 15 genes involved in the metabolic conversion of glucose to fat. A new transcription factor binding to a glucose response element of the pyruvate kinase and lipogenesis enzyme genes was discovered recently. This factor, termed carbohydrate responsive element-binding protein (ChREBP), is activated in response to high glucose and up-regulates these genes. Cyclic AMP and a high fat diet inhibit ChREBP and slow down glucose utilization. ChREBP is able to control transcription of lipogenic enzyme genes in response to nutritional and hormonal inputs, and may play an important role in disease states such as diabetes, obesity, and hypertension.
KW - Carbohydrate metabolism
KW - Glucose signaling
KW - Lipogenesis
KW - Protein phosphatase 2A
KW - Transcription factor
KW - Xylulose 5-phosphate
UR - http://www.scopus.com/inward/record.url?scp=0037098291&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0037098291&partnerID=8YFLogxK
U2 - 10.1016/S0006-2952(02)01012-2
DO - 10.1016/S0006-2952(02)01012-2
M3 - Comment/debate
C2 - 12110366
AN - SCOPUS:0037098291
SN - 0006-2952
VL - 63
SP - 2075
EP - 2080
JO - Biochemical Pharmacology
JF - Biochemical Pharmacology
IS - 12
ER -