Carcinogenesis in IBD: Potential targets for the prevention of colorectal cancer

Research output: Contribution to journalReview article

173 Scopus citations

Abstract

In patients with IBD, chronic colonic inflammation increases the risk of colorectal cancer, perhaps because inflammation predisposes these tissues to genomic instability. Carcinogenesis in the inflamed colon seems to follow a different sequence of genetic alterations than that observed in sporadic cancers in the uninflamed colon. In this Review, we focus on the genetic alterations in colitis-associated colorectal cancer that contribute to the acquisition of the essential hallmarks of cancer, and on how those alterations differ from sporadic colorectal cancers. Our intent is to provide a conceptual basis for categorizing carcinogenetic molecular abnormalities in IBD, and for understanding how cancer-preventive therapies might target reversal of acquired abnormalities in specific biochemical pathways.

Original languageEnglish (US)
Pages (from-to)297-305
Number of pages9
JournalNature Reviews Gastroenterology and Hepatology
Volume6
Issue number5
DOIs
StatePublished - Jul 27 2009

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology

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