Cardiac autonomic blockade in exercising dogs

J. M. Atkins, L. D. Horwitz

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Pharmacological blockade of autonomic control of the heart was studied in dogs performing mild, moderate, and severe running exercise on a level treadmill. The dogs were studied without drugs, after atropine, propranolol, and after both atropine and propranolol. As compared with results without drugs, cardiac denervation resulted in elevated resting heart rate (+45 beats min) but reduced heart rate during moderate (-17 beats/min) and severe exercise (-47 beats min); no change in cardiac output at rest or during mild exercise but decreases (-23% and -25%) during moderate and severe exercise; and reduced first derivatives of left ventricular pressure at rest (-24%) and during exercise (-35, -41, and -52% for mild, moderate, and severe loads, respectively). Cardiac denervation did not alter end-diastolic left ventricular diameter but significantly increased end-systolic diameter during exercise. It is concluded that blockade of autonomic control of the heart diminishes cardiac output during exercise by reducing heart rate and myocardial contractile force but does not alter cardiac output at rest.

Original languageEnglish (US)
Pages (from-to)878-883
Number of pages6
JournalJournal of Applied Physiology Respiratory Environmental and Exercise Physiology
Volume42
Issue number6
StatePublished - 1977

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Cardiac Output
Heart Rate
Denervation
Dogs
Atropine
Propranolol
Ventricular Pressure
Running
Pharmaceutical Preparations
Pharmacology

ASJC Scopus subject areas

  • Endocrinology
  • Physiology

Cite this

Cardiac autonomic blockade in exercising dogs. / Atkins, J. M.; Horwitz, L. D.

In: Journal of Applied Physiology Respiratory Environmental and Exercise Physiology, Vol. 42, No. 6, 1977, p. 878-883.

Research output: Contribution to journalArticle

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