Cardiac computed tomography assessment of the near term impact of percutaneous ventricular restoration therapy (parachute®) on mitral valve geometry

Chor Cheung Tam, Anas Fares, Amer Alaiti, Kashif Shaikh, Hüseyin Ince, Andrejs Erglis, Hiram G. Bezerra, William T. Abraham, Marco A. Costa, Guilherme F. Attizzani

Research output: Contribution to journalArticle

Abstract

Objectives: The aim of current study is to assess the near term impact of percutaneous ventricular restoration therapy (PVR), Parachute® on mitral valve (MV) geometry by cardiac computed tomography (CCT). Background: Recent data demonstrates the feasibility of PVR for treatment of post anterior myocardial infarction (MI) heart failure. Little is known, however, about the interaction of the device and left ventricular structures, particularly the MV apparatus. Methods: This is a retrospective Core Laboratory analysis of Parachute Trials’ CCT data. Patients with paired (before and after Parachute implant) CCT acquisitions were included into analysis. MV geometric parameters were measured. Results: Thirty-three patients were included in the analysis. The mean time of follow-up CCT post procedure was 188 ± 52 days. There were significant reduction in tenting height (A1P1: −1.70 ± 1.89 mm, −17.40 ± 20.20%; A2P2: −1.43 ± 1.89 mm, −12.10 ± 15.00%; A3P3: −1.54 ± 1.58 mm, −15.50 ± 15.20%, P < 0.001), tenting volume (−0.93 ± 0.60 mm3, −22.00 ± 11.40%, P < 0.001), systolic interpapillary muscle distance (−2.22 ± 2.11 mm, −7.51 ± 7.23%, P < 0.001) and diastolic interpapillary muscle distance (−3.14 ± 2.20 mm, −8.46 ± 5.73%, P < 0.001) post PVR. Conclusions: In post anterior MI heart failure patients, PVR has favorable near term impact on MV geometry as assessed by CCT.

Original languageEnglish (US)
Pages (from-to)45-51
Number of pages7
JournalCatheterization and Cardiovascular Interventions
Volume88
Issue number2
DOIs
StatePublished - Aug 1 2016
Externally publishedYes

Keywords

  • computer tomography
  • mitral valve
  • percutaneous ventricular restoration

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine

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