TY - JOUR
T1 - Cardiac effects of diphenylhydantoin (Dilantin) in man
AU - Mierzwiak, Donald S.
AU - Shapiro, William
AU - McNalley, Michael C.
AU - Mitchell, Jere H.
N1 - Funding Information:
* From the Pauline and i\dolph Weinberger Laboratory for Cardiovascular Research, Department of Internal Medicine, University of Texas Southwestern Medical School, Dallas, Texas 75235. This study was supported by grants from the U. S. Public Health Service (HE 06296 and HE 07717), the Dallas Heart .-\ssociation and Park?, Davis and Company. t Advanced Kesearch Fellow, American lieart Associatiotl. $ Established Investigator, American Heart .\ssociation.
PY - 1968/1
Y1 - 1968/1
N2 - The effect of Dilantin (diphenylhydantoin sodium) on right ventricular function was evaluated in 5 patients undergoing diagnostic cardiac catheterization. A transient negative inotropic effect on the right ventricle and an apparently induced conduction disturbance were seen following administration of Dilantin. Nausea, vomiting and hypotension were also associated with the administration of Dilantin. These findings emphasize the need for more information in order to properly utilize Dilantin as an antiarrhythmic agent.
AB - The effect of Dilantin (diphenylhydantoin sodium) on right ventricular function was evaluated in 5 patients undergoing diagnostic cardiac catheterization. A transient negative inotropic effect on the right ventricle and an apparently induced conduction disturbance were seen following administration of Dilantin. Nausea, vomiting and hypotension were also associated with the administration of Dilantin. These findings emphasize the need for more information in order to properly utilize Dilantin as an antiarrhythmic agent.
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U2 - 10.1016/0002-9149(68)90008-8
DO - 10.1016/0002-9149(68)90008-8
M3 - Article
C2 - 5634738
AN - SCOPUS:0014242286
VL - 21
SP - 20
EP - 22
JO - American Journal of Cardiology
JF - American Journal of Cardiology
SN - 0002-9149
IS - 1
ER -