TY - JOUR
T1 - Cardiac hypertrophy
T2 - Sorting out the circuitry
AU - McKinsey, Timothy A.
AU - Olson, Eric N.
PY - 1999/6
Y1 - 1999/6
N2 - Cardiac hypertrophy is an adaptive response of the heart to a variety of intrinsic and extrinsic stimuli. The hypertrophic response, during which cardiomyocytes increase in size without undergoing cell division, initially serves to compensate for decreased cardiac output; however, prolonged hypertrophy can become detrimental, resulting in dilated cardiomyopathy and heart failure. Cardiac hypertrophy requires coupling of intracellular signal transduction systems with transcription factors that activate and maintain the hypertrophic program. Over the past year, signaling pathways involving G proteins, mitogen-activated protein kinases and calcium-responsive phosphatases have emerged as critical regulators of cardiac hypertrophy.
AB - Cardiac hypertrophy is an adaptive response of the heart to a variety of intrinsic and extrinsic stimuli. The hypertrophic response, during which cardiomyocytes increase in size without undergoing cell division, initially serves to compensate for decreased cardiac output; however, prolonged hypertrophy can become detrimental, resulting in dilated cardiomyopathy and heart failure. Cardiac hypertrophy requires coupling of intracellular signal transduction systems with transcription factors that activate and maintain the hypertrophic program. Over the past year, signaling pathways involving G proteins, mitogen-activated protein kinases and calcium-responsive phosphatases have emerged as critical regulators of cardiac hypertrophy.
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U2 - 10.1016/S0959-437X(99)80040-9
DO - 10.1016/S0959-437X(99)80040-9
M3 - Article
C2 - 10377279
AN - SCOPUS:0033152768
SN - 0959-437X
VL - 9
SP - 267
EP - 274
JO - Current Opinion in Genetics and Development
JF - Current Opinion in Genetics and Development
IS - 3
ER -