Cardiac hypertrophy: Sorting out the circuitry

Timothy A. McKinsey, Eric N. Olson

Research output: Contribution to journalArticle

81 Scopus citations

Abstract

Cardiac hypertrophy is an adaptive response of the heart to a variety of intrinsic and extrinsic stimuli. The hypertrophic response, during which cardiomyocytes increase in size without undergoing cell division, initially serves to compensate for decreased cardiac output; however, prolonged hypertrophy can become detrimental, resulting in dilated cardiomyopathy and heart failure. Cardiac hypertrophy requires coupling of intracellular signal transduction systems with transcription factors that activate and maintain the hypertrophic program. Over the past year, signaling pathways involving G proteins, mitogen-activated protein kinases and calcium-responsive phosphatases have emerged as critical regulators of cardiac hypertrophy.

Original languageEnglish (US)
Pages (from-to)267-274
Number of pages8
JournalCurrent Opinion in Genetics and Development
Volume9
Issue number3
DOIs
StatePublished - Jun 1999

ASJC Scopus subject areas

  • Genetics
  • Developmental Biology

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