Cardiac hypertrophy: Sorting out the circuitry

Timothy A. McKinsey, Eric N. Olson

Research output: Contribution to journalArticle

81 Citations (Scopus)

Abstract

Cardiac hypertrophy is an adaptive response of the heart to a variety of intrinsic and extrinsic stimuli. The hypertrophic response, during which cardiomyocytes increase in size without undergoing cell division, initially serves to compensate for decreased cardiac output; however, prolonged hypertrophy can become detrimental, resulting in dilated cardiomyopathy and heart failure. Cardiac hypertrophy requires coupling of intracellular signal transduction systems with transcription factors that activate and maintain the hypertrophic program. Over the past year, signaling pathways involving G proteins, mitogen-activated protein kinases and calcium-responsive phosphatases have emerged as critical regulators of cardiac hypertrophy.

Original languageEnglish (US)
Pages (from-to)267-274
Number of pages8
JournalCurrent Opinion in Genetics and Development
Volume9
Issue number3
DOIs
StatePublished - Jun 1999

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Cardiomegaly
Dilated Cardiomyopathy
Mitogen-Activated Protein Kinases
GTP-Binding Proteins
Phosphoric Monoester Hydrolases
Cardiac Myocytes
Cardiac Output
Cell Division
Hypertrophy
Signal Transduction
Transcription Factors
Heart Failure
Calcium

ASJC Scopus subject areas

  • Genetics

Cite this

Cardiac hypertrophy : Sorting out the circuitry. / McKinsey, Timothy A.; Olson, Eric N.

In: Current Opinion in Genetics and Development, Vol. 9, No. 3, 06.1999, p. 267-274.

Research output: Contribution to journalArticle

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