Cardiac magnetic resonance imaging to assess the impact of maternal habitus on cardiac remodeling during pregnancy

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Background It is well known that the maternal cardiovascular system undergoes profound alterations throughout pregnancy. Interest in understanding these changes has led investigators to use evolving and increasingly sophisticated techniques to study these changes, most recently with 2-dimensional echocardiography. Despite its clinical utility, echocardiography has limitations, and cardiac magnetic resonance imaging (CMRI) has become increasingly used for evaluation of cardiac structure and function. Objective We used CMRI to evaluate cardiac remodeling according to maternal habitus throughout pregnancy and postpartum. Study Design This was a prospective, observational study of nulliparous women aged 18-30 years, without preexisting medical conditions, conducted from October 2012 through December 2014. Women were classified according to prepregnancy body mass index (BMI) as either normal (BMI 18.5-24.9 kg/m2) or overweight (BMI 25-35 kg/m2). All women underwent CMRI during 5 epochs throughout gestation: 12-16 weeks, 26-30 weeks, 32-36 weeks, at delivery, and 3 months' postpartum. Using left ventricular mass (LVM) as a marker of cardiac remodeling, the 2 cohorts were compared. Results There were 14 normal-weight (BMI 22.2 ± 1.3) and 9 overweight (BMI 29.1 ± 2.0) women who participated in the study. Beginning at 26-30 weeks and continuing to delivery, LVM of both normal-weight and overweight women was significantly increased compared with the respective first-trimester studies for each cohort (P

Original languageEnglish (US)
Pages (from-to)640.e1-640.e6
JournalAmerican Journal of Obstetrics and Gynecology
Volume214
Issue number5
DOIs
StatePublished - May 1 2016

Fingerprint

Body Mass Index
Mothers
Magnetic Resonance Imaging
Pregnancy
Postpartum Period
Echocardiography
Weights and Measures
Preexisting Condition Coverage
First Pregnancy Trimester
Cardiovascular System
Observational Studies
Cohort Studies
Research Personnel
Prospective Studies

Keywords

  • cardiac magnetic resonance imaging
  • cardiac remodeling
  • concentric hypertrophy
  • left ventricular mass

ASJC Scopus subject areas

  • Obstetrics and Gynecology

Cite this

@article{15f20429e97a43a19cfeaa0f4a9f1553,
title = "Cardiac magnetic resonance imaging to assess the impact of maternal habitus on cardiac remodeling during pregnancy",
abstract = "Background It is well known that the maternal cardiovascular system undergoes profound alterations throughout pregnancy. Interest in understanding these changes has led investigators to use evolving and increasingly sophisticated techniques to study these changes, most recently with 2-dimensional echocardiography. Despite its clinical utility, echocardiography has limitations, and cardiac magnetic resonance imaging (CMRI) has become increasingly used for evaluation of cardiac structure and function. Objective We used CMRI to evaluate cardiac remodeling according to maternal habitus throughout pregnancy and postpartum. Study Design This was a prospective, observational study of nulliparous women aged 18-30 years, without preexisting medical conditions, conducted from October 2012 through December 2014. Women were classified according to prepregnancy body mass index (BMI) as either normal (BMI 18.5-24.9 kg/m2) or overweight (BMI 25-35 kg/m2). All women underwent CMRI during 5 epochs throughout gestation: 12-16 weeks, 26-30 weeks, 32-36 weeks, at delivery, and 3 months' postpartum. Using left ventricular mass (LVM) as a marker of cardiac remodeling, the 2 cohorts were compared. Results There were 14 normal-weight (BMI 22.2 ± 1.3) and 9 overweight (BMI 29.1 ± 2.0) women who participated in the study. Beginning at 26-30 weeks and continuing to delivery, LVM of both normal-weight and overweight women was significantly increased compared with the respective first-trimester studies for each cohort (P",
keywords = "cardiac magnetic resonance imaging, cardiac remodeling, concentric hypertrophy, left ventricular mass",
author = "Stewart, {Robert D.} and Nelson, {David B.} and Matulevicius, {Susan A.} and Morgan, {Jamie L.} and McIntire, {Donald D.} and Drazner, {Mark H.} and Cunningham, {F. Gary}",
year = "2016",
month = "5",
day = "1",
doi = "10.1016/j.ajog.2015.11.014",
language = "English (US)",
volume = "214",
pages = "640.e1--640.e6",
journal = "American Journal of Obstetrics and Gynecology",
issn = "0002-9378",
publisher = "Mosby Inc.",
number = "5",

}

TY - JOUR

T1 - Cardiac magnetic resonance imaging to assess the impact of maternal habitus on cardiac remodeling during pregnancy

AU - Stewart, Robert D.

AU - Nelson, David B.

AU - Matulevicius, Susan A.

AU - Morgan, Jamie L.

AU - McIntire, Donald D.

AU - Drazner, Mark H.

AU - Cunningham, F. Gary

PY - 2016/5/1

Y1 - 2016/5/1

N2 - Background It is well known that the maternal cardiovascular system undergoes profound alterations throughout pregnancy. Interest in understanding these changes has led investigators to use evolving and increasingly sophisticated techniques to study these changes, most recently with 2-dimensional echocardiography. Despite its clinical utility, echocardiography has limitations, and cardiac magnetic resonance imaging (CMRI) has become increasingly used for evaluation of cardiac structure and function. Objective We used CMRI to evaluate cardiac remodeling according to maternal habitus throughout pregnancy and postpartum. Study Design This was a prospective, observational study of nulliparous women aged 18-30 years, without preexisting medical conditions, conducted from October 2012 through December 2014. Women were classified according to prepregnancy body mass index (BMI) as either normal (BMI 18.5-24.9 kg/m2) or overweight (BMI 25-35 kg/m2). All women underwent CMRI during 5 epochs throughout gestation: 12-16 weeks, 26-30 weeks, 32-36 weeks, at delivery, and 3 months' postpartum. Using left ventricular mass (LVM) as a marker of cardiac remodeling, the 2 cohorts were compared. Results There were 14 normal-weight (BMI 22.2 ± 1.3) and 9 overweight (BMI 29.1 ± 2.0) women who participated in the study. Beginning at 26-30 weeks and continuing to delivery, LVM of both normal-weight and overweight women was significantly increased compared with the respective first-trimester studies for each cohort (P

AB - Background It is well known that the maternal cardiovascular system undergoes profound alterations throughout pregnancy. Interest in understanding these changes has led investigators to use evolving and increasingly sophisticated techniques to study these changes, most recently with 2-dimensional echocardiography. Despite its clinical utility, echocardiography has limitations, and cardiac magnetic resonance imaging (CMRI) has become increasingly used for evaluation of cardiac structure and function. Objective We used CMRI to evaluate cardiac remodeling according to maternal habitus throughout pregnancy and postpartum. Study Design This was a prospective, observational study of nulliparous women aged 18-30 years, without preexisting medical conditions, conducted from October 2012 through December 2014. Women were classified according to prepregnancy body mass index (BMI) as either normal (BMI 18.5-24.9 kg/m2) or overweight (BMI 25-35 kg/m2). All women underwent CMRI during 5 epochs throughout gestation: 12-16 weeks, 26-30 weeks, 32-36 weeks, at delivery, and 3 months' postpartum. Using left ventricular mass (LVM) as a marker of cardiac remodeling, the 2 cohorts were compared. Results There were 14 normal-weight (BMI 22.2 ± 1.3) and 9 overweight (BMI 29.1 ± 2.0) women who participated in the study. Beginning at 26-30 weeks and continuing to delivery, LVM of both normal-weight and overweight women was significantly increased compared with the respective first-trimester studies for each cohort (P

KW - cardiac magnetic resonance imaging

KW - cardiac remodeling

KW - concentric hypertrophy

KW - left ventricular mass

UR - http://www.scopus.com/inward/record.url?scp=84964527165&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84964527165&partnerID=8YFLogxK

U2 - 10.1016/j.ajog.2015.11.014

DO - 10.1016/j.ajog.2015.11.014

M3 - Article

C2 - 26611998

AN - SCOPUS:84964527165

VL - 214

SP - 640.e1-640.e6

JO - American Journal of Obstetrics and Gynecology

JF - American Journal of Obstetrics and Gynecology

SN - 0002-9378

IS - 5

ER -