Cardiac Modeling for Multisystem Inflammatory Syndrome in Children (MIS-C, PIMS-TS)

Rebecca Waugh, Mohamed Abdelghafar Hussein, Jamie Weller, Kavita Sharma, Franz G Greil, Jeffrey Kahn, Mohammad T Hussain, Radomír Chabiniok

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Cardiovascular data of 8 patients with Multisystem Inflammatory Syndrome in Children (MIS-C), caused by an aberrant reaction of immune system to the SARS-CoV-2 coronarovirus, were retrospectively analyzed by using patient-specific biomechanical modeling. The first goal was to increase the understanding of the pathophysiology of the cardiovascular involvement in MIS-C, during the inpatient stay at Intensive Care Unit and after discharge from the hospital. Secondly, hypothetical action of various types of pharmacological therapy was tested in silico using the created patient-specific models, aiming to contribute into the optimal pharmacological management during the acute stage of MIS-C.

Original languageEnglish (US)
Title of host publicationFunctional Imaging and Modeling of the Heart - 11th International Conference, FIMH 2021, Proceedings
EditorsDaniel B. Ennis, Luigi E. Perotti, Vicky Y. Wang
PublisherSpringer Science and Business Media Deutschland GmbH
Pages435-446
Number of pages12
ISBN (Print)9783030787097
DOIs
StatePublished - 2021
Event11th International Conference on Functional Imaging and Modeling of the Heart, FIMH 2021 - Virtual, Online
Duration: Jun 21 2021Jun 25 2021

Publication series

NameLecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
Volume12738 LNCS
ISSN (Print)0302-9743
ISSN (Electronic)1611-3349

Conference

Conference11th International Conference on Functional Imaging and Modeling of the Heart, FIMH 2021
CityVirtual, Online
Period6/21/216/25/21

Keywords

  • Cardiac modeling
  • Cardiovascular magnetic resonance imaging (CMR)
  • Circulatory shock
  • Echocardiography
  • Heart failure
  • Intensive Care Unit (ICU) monitoring
  • Multisystem Inflammatory Syndrome in Children (MIS-C PIMS-TS)

ASJC Scopus subject areas

  • Theoretical Computer Science
  • Computer Science(all)

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