Cardiac molecular signaling after burn trauma

Deborah L. Carlson, Jureta W. Horton

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Research using mammalian burn models has defined significant cardiac deficits after burn injury. The physiologic response to burn and burn complicated by sepsis, including the cardiac dysfunction associated with these insults, remains a very complex physiologic process which, despite active study, remains unclear. The well-characterized inflammatory mediators such as tumor necrosis factor-α, interleukin-1β, and interleukin-6 continue to play an active role in mediating cardiac dysfunction. However, perhaps of greater interest are the late mediators, high mobility group box 1 and macrophage migration inhibitory factor, because they offer a very realistic window for therapeutic intervention for controlling the inflammatory response. In addition, several other mediators of cardiac dysfunction have been identified and include the heat shock proteins, apoptosis, and the inflammatory caspases. These new mediators provide opportunities for therapeutic intervention, but further research is needed to clarify the importance of their mechanisms of action and the complex interactions between these various signaling pathways.

Original languageEnglish (US)
Pages (from-to)669-675
Number of pages7
JournalJournal of Burn Care and Research
Volume27
Issue number5
DOIs
StatePublished - Sep 2006

Fingerprint

Macrophage Migration-Inhibitory Factors
Wounds and Injuries
Caspases
Heat-Shock Proteins
Interleukin-1
Research
Interleukin-6
Sepsis
Tumor Necrosis Factor-alpha
Therapeutics
Pyroptosis

ASJC Scopus subject areas

  • Emergency Medicine
  • Rehabilitation
  • Surgery

Cite this

Cardiac molecular signaling after burn trauma. / Carlson, Deborah L.; Horton, Jureta W.

In: Journal of Burn Care and Research, Vol. 27, No. 5, 09.2006, p. 669-675.

Research output: Contribution to journalArticle

Carlson, Deborah L. ; Horton, Jureta W. / Cardiac molecular signaling after burn trauma. In: Journal of Burn Care and Research. 2006 ; Vol. 27, No. 5. pp. 669-675.
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