TY - JOUR
T1 - Cardiac plasticity
AU - Hill, Joseph A
AU - Olson, Eric N
PY - 2008/3/27
Y1 - 2008/3/27
N2 - This review explains how the heart responds to physiologic or pathologic conditions. Exercise, pregnancy, and postnatal growth cause physiologic growth; neurohumoral activation, hypertension, and myocardial injury cause hypertrophic growth, which increases the risk of heart failure and malignant arrhythmia. Atrophy of the heart can arise from protracted bed rest, prolonged weightlessness, or mechanical unloading with a ventricular assist device.
AB - This review explains how the heart responds to physiologic or pathologic conditions. Exercise, pregnancy, and postnatal growth cause physiologic growth; neurohumoral activation, hypertension, and myocardial injury cause hypertrophic growth, which increases the risk of heart failure and malignant arrhythmia. Atrophy of the heart can arise from protracted bed rest, prolonged weightlessness, or mechanical unloading with a ventricular assist device.
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U2 - 10.1056/NEJMra072139
DO - 10.1056/NEJMra072139
M3 - Review article
C2 - 18367740
AN - SCOPUS:41449086790
SN - 0028-4793
VL - 358
SP - 1370
JO - New England Journal of Medicine
JF - New England Journal of Medicine
IS - 13
ER -