Cardiac retransplantation in children

Kirk R. Kanter, Robert N. Vincent, Alexandria M. Berg, William T. Mahle, Joseph M. Forbess, Paul M. Kirshbom

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

Background Experience with pediatric cardiac retransplantation is limited. Outcomes should be inspected to insure proper use of donor hearts. Methods Of 152 pediatric heart transplantations, we performed 20 retransplants in 17 children (3 had a second retransplant). The retransplant children were older than the primary transplant children (11.1 ± 4.4 years versus 7.1 ± 6.0 years; p = 0.005). Excluding 1 early retransplant, the interval from primary transplant to retransplant was 5.5 ± 3.3 years (range, 1.1 to 11.1). The retransplant patients were clinically more ill than the primary transplant patients (United Network for Organ Sharing status I, 75% versus 63%; mechanical circulatory support or dialysis, 20% versus 3.8%). Results Donor ischemia time (188 versus 165 minutes) and cardiopulmonary bypass time (127 versus 127 minutes) were not significantly different for the retransplant patients. Excluding 1 retransplant patient who required a tracheostomy, days on the ventilator (2.7 versus 2.7), days on inotropic support (3.0 versus 3.2), intensive care unit days (7.2 versus 6.7), and hospital days (15.9 versus 13.8) were similar in the retransplant group. Freedom from rejection at 90 days and 1 year was not different in the retransplant patients. Actuarial patient survival in the patients undergoing first retransplant was similar to the primary transplant patients at 30 days (95% versus 94.7%), 1 year (94.1% versus 80.7%), and 3 years (78.4% versus 73.1%). Two of 3 children receiving a third transplant died within 1 year of redo retransplantation. Conclusions Cardiac retransplantation can be performed in children with results comparable with those for primary transplantation despite increased clinical acuity. These early results suggest that cardiac retransplantation in children is a reasonable therapeutic option. Children with repeat retransplantation do not fare as well.

Original languageEnglish (US)
Pages (from-to)644-649
Number of pages6
JournalAnnals of Thoracic Surgery
Volume78
Issue number2
DOIs
StatePublished - Aug 2004

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Transplants
Tissue Donors
Pediatrics
Tracheostomy
Mechanical Ventilators
Heart Transplantation
Cardiopulmonary Bypass
Intensive Care Units
Dialysis
Ischemia
Transplantation
Survival
Therapeutics

Keywords

  • 34

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Surgery

Cite this

Kanter, K. R., Vincent, R. N., Berg, A. M., Mahle, W. T., Forbess, J. M., & Kirshbom, P. M. (2004). Cardiac retransplantation in children. Annals of Thoracic Surgery, 78(2), 644-649. https://doi.org/10.1016/j.athoracsur.2004.02.090

Cardiac retransplantation in children. / Kanter, Kirk R.; Vincent, Robert N.; Berg, Alexandria M.; Mahle, William T.; Forbess, Joseph M.; Kirshbom, Paul M.

In: Annals of Thoracic Surgery, Vol. 78, No. 2, 08.2004, p. 644-649.

Research output: Contribution to journalArticle

Kanter, KR, Vincent, RN, Berg, AM, Mahle, WT, Forbess, JM & Kirshbom, PM 2004, 'Cardiac retransplantation in children', Annals of Thoracic Surgery, vol. 78, no. 2, pp. 644-649. https://doi.org/10.1016/j.athoracsur.2004.02.090
Kanter KR, Vincent RN, Berg AM, Mahle WT, Forbess JM, Kirshbom PM. Cardiac retransplantation in children. Annals of Thoracic Surgery. 2004 Aug;78(2):644-649. https://doi.org/10.1016/j.athoracsur.2004.02.090
Kanter, Kirk R. ; Vincent, Robert N. ; Berg, Alexandria M. ; Mahle, William T. ; Forbess, Joseph M. ; Kirshbom, Paul M. / Cardiac retransplantation in children. In: Annals of Thoracic Surgery. 2004 ; Vol. 78, No. 2. pp. 644-649.
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abstract = "Background Experience with pediatric cardiac retransplantation is limited. Outcomes should be inspected to insure proper use of donor hearts. Methods Of 152 pediatric heart transplantations, we performed 20 retransplants in 17 children (3 had a second retransplant). The retransplant children were older than the primary transplant children (11.1 ± 4.4 years versus 7.1 ± 6.0 years; p = 0.005). Excluding 1 early retransplant, the interval from primary transplant to retransplant was 5.5 ± 3.3 years (range, 1.1 to 11.1). The retransplant patients were clinically more ill than the primary transplant patients (United Network for Organ Sharing status I, 75{\%} versus 63{\%}; mechanical circulatory support or dialysis, 20{\%} versus 3.8{\%}). Results Donor ischemia time (188 versus 165 minutes) and cardiopulmonary bypass time (127 versus 127 minutes) were not significantly different for the retransplant patients. Excluding 1 retransplant patient who required a tracheostomy, days on the ventilator (2.7 versus 2.7), days on inotropic support (3.0 versus 3.2), intensive care unit days (7.2 versus 6.7), and hospital days (15.9 versus 13.8) were similar in the retransplant group. Freedom from rejection at 90 days and 1 year was not different in the retransplant patients. Actuarial patient survival in the patients undergoing first retransplant was similar to the primary transplant patients at 30 days (95{\%} versus 94.7{\%}), 1 year (94.1{\%} versus 80.7{\%}), and 3 years (78.4{\%} versus 73.1{\%}). Two of 3 children receiving a third transplant died within 1 year of redo retransplantation. Conclusions Cardiac retransplantation can be performed in children with results comparable with those for primary transplantation despite increased clinical acuity. These early results suggest that cardiac retransplantation in children is a reasonable therapeutic option. Children with repeat retransplantation do not fare as well.",
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AB - Background Experience with pediatric cardiac retransplantation is limited. Outcomes should be inspected to insure proper use of donor hearts. Methods Of 152 pediatric heart transplantations, we performed 20 retransplants in 17 children (3 had a second retransplant). The retransplant children were older than the primary transplant children (11.1 ± 4.4 years versus 7.1 ± 6.0 years; p = 0.005). Excluding 1 early retransplant, the interval from primary transplant to retransplant was 5.5 ± 3.3 years (range, 1.1 to 11.1). The retransplant patients were clinically more ill than the primary transplant patients (United Network for Organ Sharing status I, 75% versus 63%; mechanical circulatory support or dialysis, 20% versus 3.8%). Results Donor ischemia time (188 versus 165 minutes) and cardiopulmonary bypass time (127 versus 127 minutes) were not significantly different for the retransplant patients. Excluding 1 retransplant patient who required a tracheostomy, days on the ventilator (2.7 versus 2.7), days on inotropic support (3.0 versus 3.2), intensive care unit days (7.2 versus 6.7), and hospital days (15.9 versus 13.8) were similar in the retransplant group. Freedom from rejection at 90 days and 1 year was not different in the retransplant patients. Actuarial patient survival in the patients undergoing first retransplant was similar to the primary transplant patients at 30 days (95% versus 94.7%), 1 year (94.1% versus 80.7%), and 3 years (78.4% versus 73.1%). Two of 3 children receiving a third transplant died within 1 year of redo retransplantation. Conclusions Cardiac retransplantation can be performed in children with results comparable with those for primary transplantation despite increased clinical acuity. These early results suggest that cardiac retransplantation in children is a reasonable therapeutic option. Children with repeat retransplantation do not fare as well.

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