Cardiac T2∗ measurement of hyperpolarized 13C metabolites using metabolite-selective multi-echo spiral imaging

Junjie Ma, Jun Chen, Galen D. Reed, Edward P. Hackett, Crystal E. Harrison, James Ratnakar, Rolf F. Schulte, Vlad Zaha, Craig R. Malloy, Jae Mo Park

Research output: Contribution to journalArticlepeer-review

Abstract

Purpose: Noninvasive imaging with hyperpolarized (HP) pyruvate can capture in vivo cardiac metabolism. For proper quantification of the metabolites and optimization of imaging parameters, understanding MR characteristics such as (Formula presented.) s of the HP signals is critical. This study is to measure in vivo cardiac (Formula presented.) s of HP [1-13C]pyruvate and the products in rodents and humans. Methods: A dynamic 13C multi-echo spiral imaging sequence that acquires [13C]bicarbonate, [1-13C]lactate, and [1-13C]pyruvate images in an interleaved manner was implemented for a clinical 3 Tesla system. (Formula presented.) of each metabolite was calculated from the multi-echo images by fitting the signal decay of each region of interest mono-exponentially. The performance of measuring (Formula presented.) using the sequence was first validated using a 13C phantom and then with rodents following a bolus injection of HP [1-13C]pyruvate. In humans, (Formula presented.) of each metabolite was calculated for left ventricle, right ventricle, and myocardium. Results: Cardiac (Formula presented.) s of HP [1-13C]pyruvate, [1-13C]lactate, and [13C]bicarbonate in rodents were measured as 24.9 ± 5.0, 16.4 ± 4.7, and 16.9 ± 3.4 ms, respectively. In humans, (Formula presented.) of [1-13C]pyruvate was 108.7 ± 22.6 ms in left ventricle and 129.4 ± 8.9 ms in right ventricle. (Formula presented.) of [1-13C]lactate was 40.9 ± 8.3, 44.2 ± 5.5, and 43.7 ± 9.0 ms in left ventricle, right ventricle, and myocardium, respectively. (Formula presented.) of [13C]bicarbonate in myocardium was 64.4 ± 2.5 ms. The measurements were reproducible and consistent over time after the pyruvate injection. Conclusion: The proposed metabolite-selective multi-echo spiral imaging sequence reliably measures in vivo cardiac (Formula presented.) s of HP [1-13C]pyruvate and products.

Original languageEnglish (US)
JournalMagnetic resonance in medicine
DOIs
StateAccepted/In press - 2021

Keywords

  • dynamic nuclear polarization
  • heart
  • hyperpolarized pyruvate
  • multi-echo spiral imaging
  • T 2 ∗

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Fingerprint Dive into the research topics of 'Cardiac T2∗ measurement of hyperpolarized <sup>13</sup>C metabolites using metabolite-selective multi-echo spiral imaging'. Together they form a unique fingerprint.

Cite this