Cardiomyocyte renewal in the human heart: Insights fromthe fall-out

Eniko Lázár, Hesham A. Sadek, Olaf Bergmann

Research output: Contribution to journalArticle

28 Scopus citations

Abstract

The capacity of the mammalian heart to regenerate cardiomyocytes has been debated over the last decades. However, limitations in existing techniques to track and identify nascent cardiomyocytes have often led to inconsistent results. Radiocarbon (14C) birth dating, in combination with other quantitative strategies, allows to establish the number and age of human cardiomyocytes, making it possible to describe their age distribution and turnover dynamics. Accurate estimates of cardiomyocyte generation in the adult heart can provide the foundation for novel regenerative strategies that aim to stimulate cardiomyocyte renewal in various cardiac pathologies.

Original languageEnglish (US)
Pages (from-to)2333-2339
Number of pages7
JournalEuropean heart journal
Volume38
Issue number30
DOIs
StatePublished - Aug 7 2017

Keywords

  • Cardiomyocyte proliferation
  • Dynamics of renewal
  • Retrospective radiocarbon dating

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Fingerprint Dive into the research topics of 'Cardiomyocyte renewal in the human heart: Insights fromthe fall-out'. Together they form a unique fingerprint.

  • Cite this