Cardiomyocyte renewal in the human heart: Insights fromthe fall-out

Eniko Lázár; Hesham A. Sadek; Olaf Bergmann

doi:10.1093/eurheartj/ehx343

Cardiomyocyte renewal in the human heart: Insights fromthe fall-out

Eniko Lázár, Hesham A. Sadek, Olaf Bergmann

Research output: Contribution to journal › Article › peer-review

105 Scopus citations

Abstract

The capacity of the mammalian heart to regenerate cardiomyocytes has been debated over the last decades. However, limitations in existing techniques to track and identify nascent cardiomyocytes have often led to inconsistent results. Radiocarbon (¹⁴C) birth dating, in combination with other quantitative strategies, allows to establish the number and age of human cardiomyocytes, making it possible to describe their age distribution and turnover dynamics. Accurate estimates of cardiomyocyte generation in the adult heart can provide the foundation for novel regenerative strategies that aim to stimulate cardiomyocyte renewal in various cardiac pathologies.

Original language	English (US)
Pages (from-to)	2333-2339
Number of pages	7
Journal	European heart journal
Volume	38
Issue number	30
DOIs	https://doi.org/10.1093/eurheartj/ehx343
State	Published - Aug 7 2017

Keywords

Cardiomyocyte proliferation
Dynamics of renewal
Retrospective radiocarbon dating

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine

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10.1093/eurheartj/ehx343

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abstract = "The capacity of the mammalian heart to regenerate cardiomyocytes has been debated over the last decades. However, limitations in existing techniques to track and identify nascent cardiomyocytes have often led to inconsistent results. Radiocarbon (14C) birth dating, in combination with other quantitative strategies, allows to establish the number and age of human cardiomyocytes, making it possible to describe their age distribution and turnover dynamics. Accurate estimates of cardiomyocyte generation in the adult heart can provide the foundation for novel regenerative strategies that aim to stimulate cardiomyocyte renewal in various cardiac pathologies.",

keywords = "Cardiomyocyte proliferation, Dynamics of renewal, Retrospective radiocarbon dating",

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N2 - The capacity of the mammalian heart to regenerate cardiomyocytes has been debated over the last decades. However, limitations in existing techniques to track and identify nascent cardiomyocytes have often led to inconsistent results. Radiocarbon (14C) birth dating, in combination with other quantitative strategies, allows to establish the number and age of human cardiomyocytes, making it possible to describe their age distribution and turnover dynamics. Accurate estimates of cardiomyocyte generation in the adult heart can provide the foundation for novel regenerative strategies that aim to stimulate cardiomyocyte renewal in various cardiac pathologies.

AB - The capacity of the mammalian heart to regenerate cardiomyocytes has been debated over the last decades. However, limitations in existing techniques to track and identify nascent cardiomyocytes have often led to inconsistent results. Radiocarbon (14C) birth dating, in combination with other quantitative strategies, allows to establish the number and age of human cardiomyocytes, making it possible to describe their age distribution and turnover dynamics. Accurate estimates of cardiomyocyte generation in the adult heart can provide the foundation for novel regenerative strategies that aim to stimulate cardiomyocyte renewal in various cardiac pathologies.

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Cardiomyocyte renewal in the human heart: Insights fromthe fall-out

Abstract

Keywords

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