Cardiopulmonary adaptations to pneumonectomy in dogs III. Ventilatory power requirements and muscle structure

C. C W Hsia, L. F. Herazo, M. Ramanathan, H. Claassen, F. Fryder-Doffey, H. Hoppeler, R. L. Johnson

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Static and dynamic mechanical characteristics of the respiratory system were measured in five adult foxhounds 6-15 mo after right pneumonectomy (R- PNX) and in five matched foxhounds that underwent right thoracotomy without pneumonectomy (Sham). In R-PNX dogs, elastic recoil was lower than that in the left lung of Sham dogs. On exercise, absolute ventilatory power requirements of the lung and its components were measured, i.e., power requirements to overcome elastic and viscous resistances of the lung as well as power requirements during inspiration and expiration. All components were higher for a given minute ventilation in R-PNX dogs than in both lungs of Sham dogs. Ventilatory power requirements after R-PNX were also higher than in three adult foxhounds after left PNX studied previously by the same techniques. After R-PNX, the mass of the right costal diaphragm and total mass of inspiratory muscles were greater than in Sham dogs. There were no significant differences in ultrastructural features of the costal diaphragm. The unilateral increase in muscle mass is likely the result of chronic elevation and stretch of the right costal diaphragm after R-PNX.

Original languageEnglish (US)
Pages (from-to)2191-2198
Number of pages8
JournalJournal of Applied Physiology
Volume76
Issue number5
StatePublished - 1994

Fingerprint

Pneumonectomy
Dogs
Muscles
Diaphragm
Lung
Thoracotomy
Respiratory System
Ventilation

Keywords

  • elastic resistance
  • exercise
  • lung resection
  • respiratory muscle morphometry
  • viscous resistance

ASJC Scopus subject areas

  • Endocrinology
  • Physiology
  • Orthopedics and Sports Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation

Cite this

Hsia, C. C. W., Herazo, L. F., Ramanathan, M., Claassen, H., Fryder-Doffey, F., Hoppeler, H., & Johnson, R. L. (1994). Cardiopulmonary adaptations to pneumonectomy in dogs III. Ventilatory power requirements and muscle structure. Journal of Applied Physiology, 76(5), 2191-2198.

Cardiopulmonary adaptations to pneumonectomy in dogs III. Ventilatory power requirements and muscle structure. / Hsia, C. C W; Herazo, L. F.; Ramanathan, M.; Claassen, H.; Fryder-Doffey, F.; Hoppeler, H.; Johnson, R. L.

In: Journal of Applied Physiology, Vol. 76, No. 5, 1994, p. 2191-2198.

Research output: Contribution to journalArticle

Hsia, CCW, Herazo, LF, Ramanathan, M, Claassen, H, Fryder-Doffey, F, Hoppeler, H & Johnson, RL 1994, 'Cardiopulmonary adaptations to pneumonectomy in dogs III. Ventilatory power requirements and muscle structure', Journal of Applied Physiology, vol. 76, no. 5, pp. 2191-2198.
Hsia CCW, Herazo LF, Ramanathan M, Claassen H, Fryder-Doffey F, Hoppeler H et al. Cardiopulmonary adaptations to pneumonectomy in dogs III. Ventilatory power requirements and muscle structure. Journal of Applied Physiology. 1994;76(5):2191-2198.
Hsia, C. C W ; Herazo, L. F. ; Ramanathan, M. ; Claassen, H. ; Fryder-Doffey, F. ; Hoppeler, H. ; Johnson, R. L. / Cardiopulmonary adaptations to pneumonectomy in dogs III. Ventilatory power requirements and muscle structure. In: Journal of Applied Physiology. 1994 ; Vol. 76, No. 5. pp. 2191-2198.
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