Cardiopulmonary stress testing in children with sickle cell disease who are on long-term erythrocytapheresis

Bibhuti B. Das, Walter Sobczyk, Salvatore Bertolone, Ashok Raj

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

The purpose of the study was to assess the feasibility and safety of symptom-limited cardiopulmonary stress testing (CPST) in children with sickle cell disease (SCD), who are on long-term erythrocytapheresis. Maximal symptom-limited CPST was performed in 16 children with SCD who were maintained on long-term erythrocytapheresis and the exercise response in this patient cohort was compared with those of a healthy control population. All patients completed the CPST without any complications. Twelve patients with SCD had significant reduction in aerobic capacity [peak oxygen consumption (VO2) <80% predicted]. No patient demonstrated evidence of myocardial ischemia. In summary, symptom-limited CPST can be performed safely in a subgroup of children with SCD and can yield valuable clinical information.

Original languageEnglish (US)
Pages (from-to)373-377
Number of pages5
JournalJournal of Pediatric Hematology/Oncology
Volume30
Issue number5
DOIs
StatePublished - May 1 2008

Keywords

  • Cardiopulmonary stress testing
  • Sickle cell disease
  • Stress testing

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Hematology
  • Oncology

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