Cardiorespiratory Fitness and White Matter Neuronal Fiber Integrity in Mild Cognitive Impairment

Kan Ding, Takashi Tarumi, David C. Zhu, Benjamin Y. Tseng, Binu P. Thomas, Marcel Turner, Justin Repshas, Diana R. Kerwin, Kyle B. Womack, Hanzhang Lu, C. Munro Cullum, Rong Zhang

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Background: Mounting evidence showed the self-reported levels of physical activity are positively associated with white matter (WM) integrity and cognitive performance in normal adults and patients with mild cognitive impairment (MCI). However, the objective measure of cardiorespiratory fitness (CRF) was not used in these studies. Objective: To determine the associations of CRF measured by maximal oxygen uptake (VO2max) with WM fiber integrity and neurocognitive performance in older adults with MCI. Methods: Eighty-one participants (age = 65±7 years, 43 women), including 26 cognitively normal older adults and 55 amnestic MCI patients, underwent VO2max test to measure CRF, diffusion tensor imaging (DTI) to assessWMfiber integrity, and neurocognitive assessment focused on memory and executive function. DTI data were analyzed by the tract-based spatial statistics and region-of-interest approach. Results: Cognitively normal older adults and MCI patients were not different in global WM fiber integrity and VO2max. VO2max was associated positively with DTI metrics of fractional anisotropy in ~54% WM fiber tracts, and negatively with mean and radial diffusivities in ~46% and ~56% of the WM fiber tracts. The associations of VO2max with DTI metrics remained statistically significant after adjustment of age, sex, body mass index, WM lesion burden, and MCI status. The DTI metrics obtained from the area that correlated to VO2max were associated with executive function performance in MCI patients. Conclusions: Higher levels of CRF are associated with better WM fiber integrity, which in turn is correlated with better executive function performance in MCI patients.

Original languageEnglish (US)
Pages (from-to)729-739
Number of pages11
JournalJournal of Alzheimer's Disease
Volume61
Issue number2
DOIs
StatePublished - Jan 1 2017

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Diffusion Tensor Imaging
Executive Function
Social Adjustment
Anisotropy
Cardiorespiratory Fitness
Cognitive Dysfunction
White Matter
Body Mass Index
Exercise
Oxygen

Keywords

  • Cardiorespiratory fitness
  • executive function
  • mild cognitive impairment
  • white matter

ASJC Scopus subject areas

  • Clinical Psychology
  • Geriatrics and Gerontology
  • Psychiatry and Mental health

Cite this

Cardiorespiratory Fitness and White Matter Neuronal Fiber Integrity in Mild Cognitive Impairment. / Ding, Kan; Tarumi, Takashi; Zhu, David C.; Tseng, Benjamin Y.; Thomas, Binu P.; Turner, Marcel; Repshas, Justin; Kerwin, Diana R.; Womack, Kyle B.; Lu, Hanzhang; Cullum, C. Munro; Zhang, Rong.

In: Journal of Alzheimer's Disease, Vol. 61, No. 2, 01.01.2017, p. 729-739.

Research output: Contribution to journalArticle

Ding, Kan ; Tarumi, Takashi ; Zhu, David C. ; Tseng, Benjamin Y. ; Thomas, Binu P. ; Turner, Marcel ; Repshas, Justin ; Kerwin, Diana R. ; Womack, Kyle B. ; Lu, Hanzhang ; Cullum, C. Munro ; Zhang, Rong. / Cardiorespiratory Fitness and White Matter Neuronal Fiber Integrity in Mild Cognitive Impairment. In: Journal of Alzheimer's Disease. 2017 ; Vol. 61, No. 2. pp. 729-739.
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abstract = "Background: Mounting evidence showed the self-reported levels of physical activity are positively associated with white matter (WM) integrity and cognitive performance in normal adults and patients with mild cognitive impairment (MCI). However, the objective measure of cardiorespiratory fitness (CRF) was not used in these studies. Objective: To determine the associations of CRF measured by maximal oxygen uptake (VO2max) with WM fiber integrity and neurocognitive performance in older adults with MCI. Methods: Eighty-one participants (age = 65±7 years, 43 women), including 26 cognitively normal older adults and 55 amnestic MCI patients, underwent VO2max test to measure CRF, diffusion tensor imaging (DTI) to assessWMfiber integrity, and neurocognitive assessment focused on memory and executive function. DTI data were analyzed by the tract-based spatial statistics and region-of-interest approach. Results: Cognitively normal older adults and MCI patients were not different in global WM fiber integrity and VO2max. VO2max was associated positively with DTI metrics of fractional anisotropy in ~54{\%} WM fiber tracts, and negatively with mean and radial diffusivities in ~46{\%} and ~56{\%} of the WM fiber tracts. The associations of VO2max with DTI metrics remained statistically significant after adjustment of age, sex, body mass index, WM lesion burden, and MCI status. The DTI metrics obtained from the area that correlated to VO2max were associated with executive function performance in MCI patients. Conclusions: Higher levels of CRF are associated with better WM fiber integrity, which in turn is correlated with better executive function performance in MCI patients.",
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AU - Ding, Kan

AU - Tarumi, Takashi

AU - Zhu, David C.

AU - Tseng, Benjamin Y.

AU - Thomas, Binu P.

AU - Turner, Marcel

AU - Repshas, Justin

AU - Kerwin, Diana R.

AU - Womack, Kyle B.

AU - Lu, Hanzhang

AU - Cullum, C. Munro

AU - Zhang, Rong

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AB - Background: Mounting evidence showed the self-reported levels of physical activity are positively associated with white matter (WM) integrity and cognitive performance in normal adults and patients with mild cognitive impairment (MCI). However, the objective measure of cardiorespiratory fitness (CRF) was not used in these studies. Objective: To determine the associations of CRF measured by maximal oxygen uptake (VO2max) with WM fiber integrity and neurocognitive performance in older adults with MCI. Methods: Eighty-one participants (age = 65±7 years, 43 women), including 26 cognitively normal older adults and 55 amnestic MCI patients, underwent VO2max test to measure CRF, diffusion tensor imaging (DTI) to assessWMfiber integrity, and neurocognitive assessment focused on memory and executive function. DTI data were analyzed by the tract-based spatial statistics and region-of-interest approach. Results: Cognitively normal older adults and MCI patients were not different in global WM fiber integrity and VO2max. VO2max was associated positively with DTI metrics of fractional anisotropy in ~54% WM fiber tracts, and negatively with mean and radial diffusivities in ~46% and ~56% of the WM fiber tracts. The associations of VO2max with DTI metrics remained statistically significant after adjustment of age, sex, body mass index, WM lesion burden, and MCI status. The DTI metrics obtained from the area that correlated to VO2max were associated with executive function performance in MCI patients. Conclusions: Higher levels of CRF are associated with better WM fiber integrity, which in turn is correlated with better executive function performance in MCI patients.

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