TY - JOUR
T1 - Cardiorespiratory fitness in survivors of cervical, endometrial, and ovarian cancers
T2 - The Cooper Center Longitudinal Study
AU - Peel, Amanda B.
AU - Barlow, Carolyn E.
AU - Leonard, David
AU - DeFina, Laura F.
AU - Jones, Lee W.
AU - Lakoski, Susan G.
N1 - Publisher Copyright:
© 2015 Elsevier Inc. All rights reserved.
PY - 2015/8/1
Y1 - 2015/8/1
N2 - Background Cardiorespiratory fitness (CRF), a strong predictor of mortality, is impaired among cancer patients. There is limited data, however, regarding CRF levels in women diagnosed with gynecologic cancers. Methods We compared CRF among ovarian, endometrial, and cervical cancer cases (n = 89) to age-matched controls (n = 89) in the Cooper Center Longitudinal Study (CCLS). CRF was evaluated by a maximal treadmill exercise tolerance test using a modified-Balke protocol. Conditional logistic regression was used to test for case-control differences in cardiorespiratory fitness, after controlling for age and body mass index, and adhering to the matched pairs design. Results The mean ages of cancer cases and controls were 50.9 years and 51.1 years, respectively (p = 0.81). Peak METs (1 MET = 3.5 mL kg- 1 min- 1) were 9.2 ± 2.0 in cancer cases compared to 10.0 ± 2.2 in controls (p = 0.03). When stratifying by type of cancer, peak METs were 8.9 ± 2.2, 8.4 ± 1.9, 9.5 ± 2.0 for patients with ovarian, endometrial, and cervical cancer, respectively. A gynecological cancer diagnosis was associated with greater odds of having 1-MET lower CRF compared to controls (OR 1.31, 95% CI: 1.05-1.64, p = 0.018), after controlling for age and BMI. Conclusion Gynecologic cancer survivors were more likely to have a 1-MET lower CRF than controls. Given a 1-MET change in CRF is associated with a significant, we advocate for more robust research regarding CRF in gynecologic cancer patients.
AB - Background Cardiorespiratory fitness (CRF), a strong predictor of mortality, is impaired among cancer patients. There is limited data, however, regarding CRF levels in women diagnosed with gynecologic cancers. Methods We compared CRF among ovarian, endometrial, and cervical cancer cases (n = 89) to age-matched controls (n = 89) in the Cooper Center Longitudinal Study (CCLS). CRF was evaluated by a maximal treadmill exercise tolerance test using a modified-Balke protocol. Conditional logistic regression was used to test for case-control differences in cardiorespiratory fitness, after controlling for age and body mass index, and adhering to the matched pairs design. Results The mean ages of cancer cases and controls were 50.9 years and 51.1 years, respectively (p = 0.81). Peak METs (1 MET = 3.5 mL kg- 1 min- 1) were 9.2 ± 2.0 in cancer cases compared to 10.0 ± 2.2 in controls (p = 0.03). When stratifying by type of cancer, peak METs were 8.9 ± 2.2, 8.4 ± 1.9, 9.5 ± 2.0 for patients with ovarian, endometrial, and cervical cancer, respectively. A gynecological cancer diagnosis was associated with greater odds of having 1-MET lower CRF compared to controls (OR 1.31, 95% CI: 1.05-1.64, p = 0.018), after controlling for age and BMI. Conclusion Gynecologic cancer survivors were more likely to have a 1-MET lower CRF than controls. Given a 1-MET change in CRF is associated with a significant, we advocate for more robust research regarding CRF in gynecologic cancer patients.
KW - Cardiorespiratory fitness
KW - Cervical cancer
KW - Endometrial cancer
KW - Gynecologic cancer
KW - Ovarian cancer
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U2 - 10.1016/j.ygyno.2015.05.027
DO - 10.1016/j.ygyno.2015.05.027
M3 - Article
C2 - 26026734
AN - SCOPUS:84938200619
SN - 0090-8258
VL - 138
SP - 394
EP - 397
JO - Gynecologic oncology
JF - Gynecologic oncology
IS - 2
ER -