Cardiorespiratory responses to stimulation of the nucleus reticularis gigantocellularis

Richard W. Stremel; Tony G. Waldrop; Christopher A. Richard; Gary A. Iwamoto

doi:10.1016/0361-9230(90)90281-4

Cardiorespiratory responses to stimulation of the nucleus reticularis gigantocellularis

Richard W. Stremel, Tony G. Waldrop, Christopher A. Richard, Gary A. Iwamoto

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Abstract

The nucleus reticularis gigantocellularis (NGC) has been shown to be involved in somatosensory and somatomotor functions. The purpose of the present study was to determine, in anesthetized cats, the modulatory influence of the portion of the NGC at the ponto-medullary border on respiratory and cardiovascular control. Electrical stimulation (25-100 μA 70 Hz, and 1.0-msec pulse duration) significantly depressed mean arterial pressure, heart rate, breathing frequency, tidal volume and phrenic amplitude. Chemical stimulation of NGC cell bodies (1.0 M L-glutamate or 10^-3 M kainic acid) elicited similar decreases in ventilation, arterial pressure and heart rate. These results show that selective activation of cell bodies in the ponto-medullary NGC can depress, in parallel, respiratory and cardiovascular activity and suggests that the influence of diverse sensory information within this region of the reticular formation must be inhibitory to respiratory and cardiovascular output.

Original language	English (US)
Pages (from-to)	1-6
Number of pages	6
Journal	Brain Research Bulletin
Volume	24
Issue number	1
DOIs	https://doi.org/10.1016/0361-9230(90)90281-4
State	Published - Jan 1990

Keywords

Bradycardia
Cat
Hypotension
Hypoventilation
Kainic acid
L-glutamate
Reticular formation

ASJC Scopus subject areas

General Neuroscience

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10.1016/0361-9230(90)90281-4

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@article{12f8809640ce4584a6e746c1663ac8f6,

title = "Cardiorespiratory responses to stimulation of the nucleus reticularis gigantocellularis",

abstract = "The nucleus reticularis gigantocellularis (NGC) has been shown to be involved in somatosensory and somatomotor functions. The purpose of the present study was to determine, in anesthetized cats, the modulatory influence of the portion of the NGC at the ponto-medullary border on respiratory and cardiovascular control. Electrical stimulation (25-100 μA 70 Hz, and 1.0-msec pulse duration) significantly depressed mean arterial pressure, heart rate, breathing frequency, tidal volume and phrenic amplitude. Chemical stimulation of NGC cell bodies (1.0 M L-glutamate or 10-3 M kainic acid) elicited similar decreases in ventilation, arterial pressure and heart rate. These results show that selective activation of cell bodies in the ponto-medullary NGC can depress, in parallel, respiratory and cardiovascular activity and suggests that the influence of diverse sensory information within this region of the reticular formation must be inhibitory to respiratory and cardiovascular output.",

keywords = "Bradycardia, Cat, Hypotension, Hypoventilation, Kainic acid, L-glutamate, Reticular formation",

author = "Stremel, {Richard W.} and Waldrop, {Tony G.} and Richard, {Christopher A.} and Iwamoto, {Gary A.}",

note = "Funding Information: Supported by NIH Grants 06296, 32487, and 29053, American Heart Association, Texas and Kentucky Affiliates, and the Lawson and Rodgers Lacy Research Fund in Cardiovascular Disease. R. W. Stremel was supported by an NIH Senior Investigator Award HL07136. The authors wish to acknowledge the excellent technical assistance of Ms. Dana Geldon and the support and guidance provided by Dr. Jere H. Mitchell.",

year = "1990",

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doi = "10.1016/0361-9230(90)90281-4",

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AU - Waldrop, Tony G.

AU - Richard, Christopher A.

AU - Iwamoto, Gary A.

N1 - Funding Information: Supported by NIH Grants 06296, 32487, and 29053, American Heart Association, Texas and Kentucky Affiliates, and the Lawson and Rodgers Lacy Research Fund in Cardiovascular Disease. R. W. Stremel was supported by an NIH Senior Investigator Award HL07136. The authors wish to acknowledge the excellent technical assistance of Ms. Dana Geldon and the support and guidance provided by Dr. Jere H. Mitchell.

PY - 1990/1

Y1 - 1990/1

N2 - The nucleus reticularis gigantocellularis (NGC) has been shown to be involved in somatosensory and somatomotor functions. The purpose of the present study was to determine, in anesthetized cats, the modulatory influence of the portion of the NGC at the ponto-medullary border on respiratory and cardiovascular control. Electrical stimulation (25-100 μA 70 Hz, and 1.0-msec pulse duration) significantly depressed mean arterial pressure, heart rate, breathing frequency, tidal volume and phrenic amplitude. Chemical stimulation of NGC cell bodies (1.0 M L-glutamate or 10-3 M kainic acid) elicited similar decreases in ventilation, arterial pressure and heart rate. These results show that selective activation of cell bodies in the ponto-medullary NGC can depress, in parallel, respiratory and cardiovascular activity and suggests that the influence of diverse sensory information within this region of the reticular formation must be inhibitory to respiratory and cardiovascular output.

AB - The nucleus reticularis gigantocellularis (NGC) has been shown to be involved in somatosensory and somatomotor functions. The purpose of the present study was to determine, in anesthetized cats, the modulatory influence of the portion of the NGC at the ponto-medullary border on respiratory and cardiovascular control. Electrical stimulation (25-100 μA 70 Hz, and 1.0-msec pulse duration) significantly depressed mean arterial pressure, heart rate, breathing frequency, tidal volume and phrenic amplitude. Chemical stimulation of NGC cell bodies (1.0 M L-glutamate or 10-3 M kainic acid) elicited similar decreases in ventilation, arterial pressure and heart rate. These results show that selective activation of cell bodies in the ponto-medullary NGC can depress, in parallel, respiratory and cardiovascular activity and suggests that the influence of diverse sensory information within this region of the reticular formation must be inhibitory to respiratory and cardiovascular output.

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KW - Kainic acid

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KW - Reticular formation

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Cardiorespiratory responses to stimulation of the nucleus reticularis gigantocellularis

Abstract

Keywords

ASJC Scopus subject areas

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