Cardiorespiratory responses to stimulation of the nucleus reticularis gigantocellularis

Richard W. Stremel, Tony G. Waldrop, Christopher A. Richard, Gary A. Iwamoto

Research output: Contribution to journalArticlepeer-review

15 Scopus citations


The nucleus reticularis gigantocellularis (NGC) has been shown to be involved in somatosensory and somatomotor functions. The purpose of the present study was to determine, in anesthetized cats, the modulatory influence of the portion of the NGC at the ponto-medullary border on respiratory and cardiovascular control. Electrical stimulation (25-100 μA 70 Hz, and 1.0-msec pulse duration) significantly depressed mean arterial pressure, heart rate, breathing frequency, tidal volume and phrenic amplitude. Chemical stimulation of NGC cell bodies (1.0 M L-glutamate or 10-3 M kainic acid) elicited similar decreases in ventilation, arterial pressure and heart rate. These results show that selective activation of cell bodies in the ponto-medullary NGC can depress, in parallel, respiratory and cardiovascular activity and suggests that the influence of diverse sensory information within this region of the reticular formation must be inhibitory to respiratory and cardiovascular output.

Original languageEnglish (US)
Pages (from-to)1-6
Number of pages6
JournalBrain Research Bulletin
Issue number1
StatePublished - Jan 1990


  • Bradycardia
  • Cat
  • Hypotension
  • Hypoventilation
  • Kainic acid
  • L-glutamate
  • Reticular formation

ASJC Scopus subject areas

  • Neuroscience(all)


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