Cardiovascular and renal nerve responses to static muscle contraction of decerebrate rabbits

L. B. Wilson, C. K. Dyke, J. A. Pawelczyk, P. T. Wall, J. H. Mitchell

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

The purpose of this study was to determine whether the biphasic arterial blood pressure responses elicited by static muscle contraction of decerebrate rabbits are mediated, at least in part, by an initial decrease and a subsequent increase in sympathetic outflow. Renal sympathetic nerve activity (RSNA) was used as an index of sympathetic outflow. Static contraction of the triceps surae muscle (n = 14) initially decreased mean arterial blood pressure (MAP) -20 ± 3 mmHg and heart rate (HR) -15 ± 5 beats/min (nadir values). After this initial decrease, MAP increased 12 ± 2 mmHg (peak increase) above baseline and there was a tendency for HR to be elevated (6 ± 3 beats/min). The changes in RSNA during muscle contraction (n = 6) mirrored the nadir and peak responses of MAP (-50 ± 9 and 32 ± 11%). Muscle stretch (n = 11) also evoked similar nadir and peak responses of MAP (-20 ± 5 and 9 ± 1 mmHg), HR (-17 ± 7 and 3 ± 3 beats/min), and RSNA (-43 ± 9 and 46 ± 15%). These data suggest that the initial depressor and subsequent pressor responses elicited by skeletal muscle contraction and stretch are mediated, at least in part, by biphasic changes in sympathetic outflow.

Original languageEnglish (US)
Pages (from-to)2449-2455
Number of pages7
JournalJournal of Applied Physiology
Volume77
Issue number5
StatePublished - 1994

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Muscle Contraction
Arterial Pressure
Rabbits
Kidney
Heart Rate
Muscles
Skeletal Muscle

Keywords

  • muscle afferents
  • pressor reflex
  • sympathetic nerve activity

ASJC Scopus subject areas

  • Endocrinology
  • Physiology
  • Orthopedics and Sports Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation

Cite this

Cardiovascular and renal nerve responses to static muscle contraction of decerebrate rabbits. / Wilson, L. B.; Dyke, C. K.; Pawelczyk, J. A.; Wall, P. T.; Mitchell, J. H.

In: Journal of Applied Physiology, Vol. 77, No. 5, 1994, p. 2449-2455.

Research output: Contribution to journalArticle

Wilson, L. B. ; Dyke, C. K. ; Pawelczyk, J. A. ; Wall, P. T. ; Mitchell, J. H. / Cardiovascular and renal nerve responses to static muscle contraction of decerebrate rabbits. In: Journal of Applied Physiology. 1994 ; Vol. 77, No. 5. pp. 2449-2455.
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