Cardiovascular autophagy Concepts, controversies, and perspectives

Sergio Lavandero, Rodrigo Troncoso, Beverly A. Rotherme, Wim Martinet, Junichi Sadoshima, Joseph A Hill

Research output: Contribution to journalReview article

111 Scopus citations

Abstract

Abbreviations: AMPK, AMP-activated protein kinase; ATG, autophagy-related; ER, endoplasmic reticulum; GSK3B/GSK-3β glycogen synthase kinase 3 beta; HDAC, histone deacetylase; HDACi, HDAC inhibitor; IP3, inositol 1,4,5-trisphosphate; I/R, ischemia/reperfusion; ITPR, inositol 1,4,5-trisphosphate receptor; LC3, microtubule-associated protein 1 light chain 3 (homolog of yeast Atg8); MTOR, mechanistic target of rapamycin; NAD+, nicotinamide adenine dinucleotide; PIK3C3/VSP34, phosphatidylinositol 3-kinase, catalytic subunit type 3; PKA, cAMP-dependent protein kinase; PtdIns3K, phosphatidylinositol 3-kinase; ULK, unc-51 like autophagy activating kinase; VSMC, vascular smooth muscle cells; WDFY3/ALFY, WD repeat and FYVE domain containing 3.

Original languageEnglish (US)
Pages (from-to)1455-1466
Number of pages12
JournalAutophagy
Volume9
Issue number10
DOIs
StatePublished - Oct 2013

Keywords

  • Atherosclerosis
  • Autophagy
  • Blood vessels
  • Cardiac hypertrophy
  • Cardiomyocyte
  • Cardiovascular diseases
  • Cardiovascular system
  • Cell signaling
  • Heart
  • Heart failure
  • Myocardial infarction
  • Regulation
  • Vascular muscle smooth cells

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

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