TY - JOUR
T1 - Cardiovascular autophagy Concepts, controversies, and perspectives
AU - Lavandero, Sergio
AU - Troncoso, Rodrigo
AU - Rotherme, Beverly A.
AU - Martinet, Wim
AU - Sadoshima, Junichi
AU - Hill, Joseph A
N1 - Funding Information:
This work was supported by Grants from CONICYT, Chile (FONDECYT 1120212 and FONDECYT 3110114 to SL and RT, respectively; Anillo ACT grant 1111 to SL, Red 120003 to SL and JAH), the NIH (HL-080144, JAH; HL-0980842, JAH; HL-100401, JAH; HL-072016, BAR; HL-097768, BAR), CPRIT (RP110486P3, JAH), the AHA DeHaan Foundation (0970518N, JAH), and the Fondation Leducq (11CVD04, JAH).
PY - 2013/10
Y1 - 2013/10
N2 - Abbreviations: AMPK, AMP-activated protein kinase; ATG, autophagy-related; ER, endoplasmic reticulum; GSK3B/GSK-3β glycogen synthase kinase 3 beta; HDAC, histone deacetylase; HDACi, HDAC inhibitor; IP3, inositol 1,4,5-trisphosphate; I/R, ischemia/reperfusion; ITPR, inositol 1,4,5-trisphosphate receptor; LC3, microtubule-associated protein 1 light chain 3 (homolog of yeast Atg8); MTOR, mechanistic target of rapamycin; NAD+, nicotinamide adenine dinucleotide; PIK3C3/VSP34, phosphatidylinositol 3-kinase, catalytic subunit type 3; PKA, cAMP-dependent protein kinase; PtdIns3K, phosphatidylinositol 3-kinase; ULK, unc-51 like autophagy activating kinase; VSMC, vascular smooth muscle cells; WDFY3/ALFY, WD repeat and FYVE domain containing 3.
AB - Abbreviations: AMPK, AMP-activated protein kinase; ATG, autophagy-related; ER, endoplasmic reticulum; GSK3B/GSK-3β glycogen synthase kinase 3 beta; HDAC, histone deacetylase; HDACi, HDAC inhibitor; IP3, inositol 1,4,5-trisphosphate; I/R, ischemia/reperfusion; ITPR, inositol 1,4,5-trisphosphate receptor; LC3, microtubule-associated protein 1 light chain 3 (homolog of yeast Atg8); MTOR, mechanistic target of rapamycin; NAD+, nicotinamide adenine dinucleotide; PIK3C3/VSP34, phosphatidylinositol 3-kinase, catalytic subunit type 3; PKA, cAMP-dependent protein kinase; PtdIns3K, phosphatidylinositol 3-kinase; ULK, unc-51 like autophagy activating kinase; VSMC, vascular smooth muscle cells; WDFY3/ALFY, WD repeat and FYVE domain containing 3.
KW - Atherosclerosis
KW - Autophagy
KW - Blood vessels
KW - Cardiac hypertrophy
KW - Cardiomyocyte
KW - Cardiovascular diseases
KW - Cardiovascular system
KW - Cell signaling
KW - Heart
KW - Heart failure
KW - Myocardial infarction
KW - Regulation
KW - Vascular muscle smooth cells
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U2 - 10.4161/auto.25969
DO - 10.4161/auto.25969
M3 - Review article
C2 - 23959233
AN - SCOPUS:84885580133
SN - 1554-8627
VL - 9
SP - 1455
EP - 1466
JO - Autophagy
JF - Autophagy
IS - 10
ER -