Cardiovascular disease following hematopoietic stem cell transplantation: Pathogenesis, detection, and the cardioprotective role of aerobic training

Jessica M. Scott, Saro Armenian, Sergio Giralt, Javid Moslehi, Thomas Wang, Lee W. Jones

Research output: Contribution to journalReview article

11 Scopus citations

Abstract

Advances in hematopoietic cell transplantation (HCT) techniques and supportive care strategies have led to dramatic improvements in relapse mortality in patients with high-risk hematological malignancies. These improvements, however, conversely increase the risk of late-occurring non-cancer competing causes, mostly cardiovascular disease (CVD). HCT recipients have a significantly increased risk of CVD-specific mortality, including elevated incidence of coronary artery disease (CAD), cerebrovascular disease, and heart failure (HF) compared to age-matched counterparts. Accordingly, there is an urgent need to identify techniques for the detection of early CVD in HCT patients to inform early prevention strategies. Aerobic training (AT) is established as the cornerstone of primary and secondary disease prevention in multiple clinical settings, and may confer similar benefits in HCT patients at high-risk of CVD. The potential benefits of AT either before, immediately after, or in the months/years following HCT have received limited attention. Here, we discuss the risk and extent of CVD in adult HCT patients, highlight novel tools for early detection of CVD, and review existing evidence in oncology and non-oncology populations supporting the efficacy of AT to attenuate HCT-induced CVD. This knowledge can be utilized to optimize treatment, while minimizing CVD risk in individuals with hematological malignancies undergoing HCT.

Original languageEnglish (US)
Pages (from-to)222-234
Number of pages13
JournalCritical Reviews in Oncology/Hematology
Volume98
DOIs
StatePublished - Feb 1 2016
Externally publishedYes

Keywords

  • Cardiovascular disease
  • Detection
  • Exercise
  • Hematopoietic stem cell transplantation

ASJC Scopus subject areas

  • Hematology
  • Oncology

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