Abstract
In two different medical centers, a total of 24 normal individuals (mean age, 31 years) participated in a double-masked, three-way crossover single-instillation comparison of betaxolol 1%, timolol 0.5%, and placebo. After each ocular treatment, cardiovascular characteristics were measured during ten-minute treadmill exercise periods. No significant differences in heart rate or double product (heart rate x systolic pressure) were seen between treatment with betaxolol and administration of placebo. However, when the same subjects were treated with timolol, they demonstrated significant (P<.05) reductions in these values at various measurement times compared with placebo and betaxolol treatments. No significant differences in mean arterial pressure were detected after any of the treatments.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 173-175 |
| Number of pages | 3 |
| Journal | American Journal of Ophthalmology |
| Volume | 99 |
| Issue number | 2 |
| State | Published - Feb 15 1985 |
Fingerprint
ASJC Scopus subject areas
- Ophthalmology
Cite this
Cardiovascular effects of topical beta-blockers during exercise. / Atkins, James M; Pugh, Billie R.; Timewell, Roger M.
In: American Journal of Ophthalmology, Vol. 99, No. 2, 15.02.1985, p. 173-175.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Cardiovascular effects of topical beta-blockers during exercise
AU - Atkins, James M
AU - Pugh, Billie R.
AU - Timewell, Roger M.
PY - 1985/2/15
Y1 - 1985/2/15
N2 - In two different medical centers, a total of 24 normal individuals (mean age, 31 years) participated in a double-masked, three-way crossover single-instillation comparison of betaxolol 1%, timolol 0.5%, and placebo. After each ocular treatment, cardiovascular characteristics were measured during ten-minute treadmill exercise periods. No significant differences in heart rate or double product (heart rate x systolic pressure) were seen between treatment with betaxolol and administration of placebo. However, when the same subjects were treated with timolol, they demonstrated significant (P<.05) reductions in these values at various measurement times compared with placebo and betaxolol treatments. No significant differences in mean arterial pressure were detected after any of the treatments.
AB - In two different medical centers, a total of 24 normal individuals (mean age, 31 years) participated in a double-masked, three-way crossover single-instillation comparison of betaxolol 1%, timolol 0.5%, and placebo. After each ocular treatment, cardiovascular characteristics were measured during ten-minute treadmill exercise periods. No significant differences in heart rate or double product (heart rate x systolic pressure) were seen between treatment with betaxolol and administration of placebo. However, when the same subjects were treated with timolol, they demonstrated significant (P<.05) reductions in these values at various measurement times compared with placebo and betaxolol treatments. No significant differences in mean arterial pressure were detected after any of the treatments.
UR - http://www.scopus.com/inward/record.url?scp=0021951369&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0021951369&partnerID=8YFLogxK
M3 - Article
C2 - 3970121
AN - SCOPUS:0021951369
VL - 99
SP - 173
EP - 175
JO - American Journal of Ophthalmology
JF - American Journal of Ophthalmology
SN - 0002-9394
IS - 2
ER -