TY - JOUR
T1 - Cardiovascular effects of topical beta-blockers during exercise
AU - Atkins, James M
AU - Pugh, Billie R.
AU - Timewell, Roger M.
N1 - Funding Information:
From the Pauline and Adolf Weinberger Laboratory for Cardiovascular Research, Department of Internal Medicine, University of Texas Health Science Center at Dallas, Southwestern Medical School, Dallas, Texas (Dr. Atkins), the Cardiac Rehabilitation Center, All Saints Episcopal Hospital, Fort Worth, Texas (Dr. Pugh), and the Department of Ophthalmology, Alcon Laboratories, Inc., Fort Worth, Texas (Dr. Timewell). This study was supported in part by a grant from Alcon Laboratories, Inc.
PY - 1985/2/15
Y1 - 1985/2/15
N2 - In two different medical centers, a total of 24 normal individuals (mean age, 31 years) participated in a double-masked, three-way crossover single-instillation comparison of betaxolol 1%, timolol 0.5%, and placebo. After each ocular treatment, cardiovascular characteristics were measured during ten-minute treadmill exercise periods. No significant differences in heart rate or double product (heart rate x systolic pressure) were seen between treatment with betaxolol and administration of placebo. However, when the same subjects were treated with timolol, they demonstrated significant (P<.05) reductions in these values at various measurement times compared with placebo and betaxolol treatments. No significant differences in mean arterial pressure were detected after any of the treatments.
AB - In two different medical centers, a total of 24 normal individuals (mean age, 31 years) participated in a double-masked, three-way crossover single-instillation comparison of betaxolol 1%, timolol 0.5%, and placebo. After each ocular treatment, cardiovascular characteristics were measured during ten-minute treadmill exercise periods. No significant differences in heart rate or double product (heart rate x systolic pressure) were seen between treatment with betaxolol and administration of placebo. However, when the same subjects were treated with timolol, they demonstrated significant (P<.05) reductions in these values at various measurement times compared with placebo and betaxolol treatments. No significant differences in mean arterial pressure were detected after any of the treatments.
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U2 - 10.1016/0002-9394(85)90227-2
DO - 10.1016/0002-9394(85)90227-2
M3 - Article
C2 - 3970121
AN - SCOPUS:0021951369
VL - 99
SP - 173
EP - 175
JO - American Journal of Ophthalmology
JF - American Journal of Ophthalmology
SN - 0002-9394
IS - 2
ER -