TY - JOUR
T1 - Cardiovascular effects of topical beta-blockers during exercise
AU - Atkins, James M
AU - Pugh, Billie R.
AU - Timewell, Roger M.
PY - 1985/2/15
Y1 - 1985/2/15
N2 - In two different medical centers, a total of 24 normal individuals (mean age, 31 years) participated in a double-masked, three-way crossover single-instillation comparison of betaxolol 1%, timolol 0.5%, and placebo. After each ocular treatment, cardiovascular characteristics were measured during ten-minute treadmill exercise periods. No significant differences in heart rate or double product (heart rate x systolic pressure) were seen between treatment with betaxolol and administration of placebo. However, when the same subjects were treated with timolol, they demonstrated significant (P<.05) reductions in these values at various measurement times compared with placebo and betaxolol treatments. No significant differences in mean arterial pressure were detected after any of the treatments.
AB - In two different medical centers, a total of 24 normal individuals (mean age, 31 years) participated in a double-masked, three-way crossover single-instillation comparison of betaxolol 1%, timolol 0.5%, and placebo. After each ocular treatment, cardiovascular characteristics were measured during ten-minute treadmill exercise periods. No significant differences in heart rate or double product (heart rate x systolic pressure) were seen between treatment with betaxolol and administration of placebo. However, when the same subjects were treated with timolol, they demonstrated significant (P<.05) reductions in these values at various measurement times compared with placebo and betaxolol treatments. No significant differences in mean arterial pressure were detected after any of the treatments.
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U2 - 10.1016/0002-9394(85)90227-2
DO - 10.1016/0002-9394(85)90227-2
M3 - Article
C2 - 3970121
AN - SCOPUS:0021951369
VL - 99
SP - 173
EP - 175
JO - American Journal of Ophthalmology
JF - American Journal of Ophthalmology
SN - 0002-9394
IS - 2
ER -