Cardiovascular function and survival during severe systemic hypoxaemia: Influence of glucosepotassium-insulin solution and of beta-blockade

Kern Wildenthal, J. Stanley Crie, George F. Vastagh

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

AUTHORS' SYNOPSIS: Anaesthetized dogs were ventilated with 3·6% O2 after having been given infusions of isotonic saline or glucose-potassium-insulin (GKI) solution. Initial tachycardia and hypertension were superseded by progressive circulatory failure and death in all dogs. In the absence of beta-adrenergic blockade, no significant differences in haemodynamic responses or survival times occurred in the animals that received the two solutions. Propranolol, itself, increased the survival time in both groups. In addition, after pretreatment with propranolol, which prevented a rise in blood glucose after the onset of hypoxia, dogs that received GKI survived significantly longer than those with persistently low blood glucose levels.

Original languageEnglish (US)
Pages (from-to)174-180
Number of pages7
JournalCardiovascular Research
Volume7
Issue number2
DOIs
StatePublished - Mar 1973

Fingerprint

Insulin
Glucose
Survival Time
Dogs
Propranolol
Blood
Blood Glucose
Dog, Anesthetized
Hypoxia
Hypertension
Hemodynamics
Potassium
Tachycardia
Adrenergic Agents
Response Time
Shock
Animals
Influence
Dog

ASJC Scopus subject areas

  • Statistics, Probability and Uncertainty
  • Applied Mathematics
  • Physiology (medical)
  • Physiology
  • Cardiology and Cardiovascular Medicine

Cite this

Cardiovascular function and survival during severe systemic hypoxaemia : Influence of glucosepotassium-insulin solution and of beta-blockade. / Wildenthal, Kern; Crie, J. Stanley; Vastagh, George F.

In: Cardiovascular Research, Vol. 7, No. 2, 03.1973, p. 174-180.

Research output: Contribution to journalArticle

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