Cardiovascular function and survival during severe systemic hypoxaemia: Influence of glucosepotassium-insulin solution and of beta-blockade

Kern Wildenthal, J. Stanley Crie, George F. Vastagh

Research output: Contribution to journalArticle

4 Scopus citations


AUTHORS' SYNOPSIS: Anaesthetized dogs were ventilated with 3·6% O2 after having been given infusions of isotonic saline or glucose-potassium-insulin (GKI) solution. Initial tachycardia and hypertension were superseded by progressive circulatory failure and death in all dogs. In the absence of beta-adrenergic blockade, no significant differences in haemodynamic responses or survival times occurred in the animals that received the two solutions. Propranolol, itself, increased the survival time in both groups. In addition, after pretreatment with propranolol, which prevented a rise in blood glucose after the onset of hypoxia, dogs that received GKI survived significantly longer than those with persistently low blood glucose levels.

Original languageEnglish (US)
Pages (from-to)174-180
Number of pages7
JournalCardiovascular Research
Issue number2
StatePublished - Mar 1973


ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

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