TY - JOUR
T1 - Cardiovascular magnetic resonance findings in a pediatric population with isolated left ventricular non-compaction
AU - Uribe, Sergio
AU - Cadavid, Lina
AU - Hussain, Tarique
AU - Parra, Rodrigo
AU - Urcelay, Gonzalo
AU - Heusser, Felipe
AU - Andía, Marcelo
AU - Tejos, Cristian
AU - Irarrazaval, Pablo
N1 - Funding Information:
The authors thank the Vicerrectoria de Investigación y Doctorado at Pontificia Universidad Catolica de Chile and Conicyt for funding support (Fondecyt 11100427 and Anillo ACT079).
PY - 2012
Y1 - 2012
N2 - Background: Isolated Left Ventricular Non-compaction (LVNC) is an uncommon disorder characterized by the presence of increased trabeculations and deep intertrabecular recesses. In adults, it has been found that Ejection Fraction (EF) decreases significantly as non-compaction severity increases. In children however, there are a few data describing the relation between anatomical characteristics of LVNC and ventricular function. We aimed to find correlations between morphological features and ventricular performance in children and young adolescents with LVNC using Cardiovascular Magnetic Resonance (CMR). Methods. 15 children with LVNC (10 males, mean age 9.7 y.o., range 0.6 - 17 y.o.), underwent a CMR scan. Different morphological measures such as the Compacted Myocardial Mass (CMM), Non-Compaction (NC) to the Compaction (C) distance ratio, Compacted Myocardial Area (CMA) and Non-Compacted Myocardial Area (NCMA), distribution of NC, and the assessment of ventricular wall motion abnormalities were performed to investigate correlations with ventricular performance. EF was considered normal over 53%. Results: The distribution of non-compaction in children was similar to published adult data with a predilection for apical, mid-inferior and mid-lateral segments. Five patients had systolic dysfunction with decreased EF. The number of affected segments was the strongest predictor of systolic dysfunction, all five patients had greater than 9 affected segments. Basal segments were less commonly affected but they were affected only in these five severe cases. Conclusion: The segmental pattern of involvement of non-compaction in children is similar to that seen in adults. Systolic dysfunction in children is closely related to the number of affected segments.
AB - Background: Isolated Left Ventricular Non-compaction (LVNC) is an uncommon disorder characterized by the presence of increased trabeculations and deep intertrabecular recesses. In adults, it has been found that Ejection Fraction (EF) decreases significantly as non-compaction severity increases. In children however, there are a few data describing the relation between anatomical characteristics of LVNC and ventricular function. We aimed to find correlations between morphological features and ventricular performance in children and young adolescents with LVNC using Cardiovascular Magnetic Resonance (CMR). Methods. 15 children with LVNC (10 males, mean age 9.7 y.o., range 0.6 - 17 y.o.), underwent a CMR scan. Different morphological measures such as the Compacted Myocardial Mass (CMM), Non-Compaction (NC) to the Compaction (C) distance ratio, Compacted Myocardial Area (CMA) and Non-Compacted Myocardial Area (NCMA), distribution of NC, and the assessment of ventricular wall motion abnormalities were performed to investigate correlations with ventricular performance. EF was considered normal over 53%. Results: The distribution of non-compaction in children was similar to published adult data with a predilection for apical, mid-inferior and mid-lateral segments. Five patients had systolic dysfunction with decreased EF. The number of affected segments was the strongest predictor of systolic dysfunction, all five patients had greater than 9 affected segments. Basal segments were less commonly affected but they were affected only in these five severe cases. Conclusion: The segmental pattern of involvement of non-compaction in children is similar to that seen in adults. Systolic dysfunction in children is closely related to the number of affected segments.
KW - cardiomyopathy
KW - isolated left ventricular non-compaction
KW - prominent trabeculations
KW - spongy myocardium
KW - ventricular performance
UR - http://www.scopus.com/inward/record.url?scp=84860598486&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84860598486&partnerID=8YFLogxK
U2 - 10.1186/1532-429X-14-9
DO - 10.1186/1532-429X-14-9
M3 - Article
C2 - 22293172
AN - SCOPUS:84860598486
SN - 1097-6647
VL - 14
JO - Journal of Cardiovascular Magnetic Resonance
JF - Journal of Cardiovascular Magnetic Resonance
IS - 1
M1 - 9
ER -