Cardiovascular responses to hyperosmotic mannitol in anesthetized and conscious dogs

James M Atkins, K. Wildenthal, L. D. Horwitz

Research output: Chapter in Book/Report/Conference proceedingChapter

22 Citations (Scopus)

Abstract

Intravenous infusions of 25% mannitol solution were given in doses of 1.25 ml/kg and 5 ml/kg to anesthetized and conscious dogs. Serum osmolality rose by 3-8 with the smaller dose and 15-25 mOsm/kg H2O with the larger dose. After the smaller dose, stroke volume and left ventricular maximal dp/dt rose significantly, while no change occurred in left ventricular end diastolic pressure. At the larger dose, further increases in stroke volume and max dp/dt were accompanied by significant elevations in heart rate, mean aortic pressure, and left ventricular end diastolic pressure. Increases in max d ln p/dt also occurred with each infusion. Changes were similar, but slightly less marked, after pretreatment with propranolol. Thus, doses of hypertonic mannitol that are feasible in the clinical setting cause significant hemodynamic alterations in the intact animal, including a substantial direct inotropic effect on the heart. The increased contractile force of the left ventricle is not dependent on changes in sympathetic nervous activity or the Frank Starling mechanism.

Original languageEnglish (US)
Title of host publicationAmerican Journal of Physiology
Pages132-137
Number of pages6
Volume225
Edition1
StatePublished - 1973

Fingerprint

Mannitol
Stroke Volume
Dogs
Blood Pressure
Starlings
Intravenous Infusions
Propranolol
Osmolar Concentration
Heart Ventricles
Arterial Pressure
Heart Rate
Hemodynamics
Serum

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Atkins, J. M., Wildenthal, K., & Horwitz, L. D. (1973). Cardiovascular responses to hyperosmotic mannitol in anesthetized and conscious dogs. In American Journal of Physiology (1 ed., Vol. 225, pp. 132-137)

Cardiovascular responses to hyperosmotic mannitol in anesthetized and conscious dogs. / Atkins, James M; Wildenthal, K.; Horwitz, L. D.

American Journal of Physiology. Vol. 225 1. ed. 1973. p. 132-137.

Research output: Chapter in Book/Report/Conference proceedingChapter

Atkins, JM, Wildenthal, K & Horwitz, LD 1973, Cardiovascular responses to hyperosmotic mannitol in anesthetized and conscious dogs. in American Journal of Physiology. 1 edn, vol. 225, pp. 132-137.
Atkins JM, Wildenthal K, Horwitz LD. Cardiovascular responses to hyperosmotic mannitol in anesthetized and conscious dogs. In American Journal of Physiology. 1 ed. Vol. 225. 1973. p. 132-137
Atkins, James M ; Wildenthal, K. ; Horwitz, L. D. / Cardiovascular responses to hyperosmotic mannitol in anesthetized and conscious dogs. American Journal of Physiology. Vol. 225 1. ed. 1973. pp. 132-137
@inbook{9bf4217f03e8418dbd4caab31fa64417,
title = "Cardiovascular responses to hyperosmotic mannitol in anesthetized and conscious dogs",
abstract = "Intravenous infusions of 25{\%} mannitol solution were given in doses of 1.25 ml/kg and 5 ml/kg to anesthetized and conscious dogs. Serum osmolality rose by 3-8 with the smaller dose and 15-25 mOsm/kg H2O with the larger dose. After the smaller dose, stroke volume and left ventricular maximal dp/dt rose significantly, while no change occurred in left ventricular end diastolic pressure. At the larger dose, further increases in stroke volume and max dp/dt were accompanied by significant elevations in heart rate, mean aortic pressure, and left ventricular end diastolic pressure. Increases in max d ln p/dt also occurred with each infusion. Changes were similar, but slightly less marked, after pretreatment with propranolol. Thus, doses of hypertonic mannitol that are feasible in the clinical setting cause significant hemodynamic alterations in the intact animal, including a substantial direct inotropic effect on the heart. The increased contractile force of the left ventricle is not dependent on changes in sympathetic nervous activity or the Frank Starling mechanism.",
author = "Atkins, {James M} and K. Wildenthal and Horwitz, {L. D.}",
year = "1973",
language = "English (US)",
volume = "225",
pages = "132--137",
booktitle = "American Journal of Physiology",
edition = "1",

}

TY - CHAP

T1 - Cardiovascular responses to hyperosmotic mannitol in anesthetized and conscious dogs

AU - Atkins, James M

AU - Wildenthal, K.

AU - Horwitz, L. D.

PY - 1973

Y1 - 1973

N2 - Intravenous infusions of 25% mannitol solution were given in doses of 1.25 ml/kg and 5 ml/kg to anesthetized and conscious dogs. Serum osmolality rose by 3-8 with the smaller dose and 15-25 mOsm/kg H2O with the larger dose. After the smaller dose, stroke volume and left ventricular maximal dp/dt rose significantly, while no change occurred in left ventricular end diastolic pressure. At the larger dose, further increases in stroke volume and max dp/dt were accompanied by significant elevations in heart rate, mean aortic pressure, and left ventricular end diastolic pressure. Increases in max d ln p/dt also occurred with each infusion. Changes were similar, but slightly less marked, after pretreatment with propranolol. Thus, doses of hypertonic mannitol that are feasible in the clinical setting cause significant hemodynamic alterations in the intact animal, including a substantial direct inotropic effect on the heart. The increased contractile force of the left ventricle is not dependent on changes in sympathetic nervous activity or the Frank Starling mechanism.

AB - Intravenous infusions of 25% mannitol solution were given in doses of 1.25 ml/kg and 5 ml/kg to anesthetized and conscious dogs. Serum osmolality rose by 3-8 with the smaller dose and 15-25 mOsm/kg H2O with the larger dose. After the smaller dose, stroke volume and left ventricular maximal dp/dt rose significantly, while no change occurred in left ventricular end diastolic pressure. At the larger dose, further increases in stroke volume and max dp/dt were accompanied by significant elevations in heart rate, mean aortic pressure, and left ventricular end diastolic pressure. Increases in max d ln p/dt also occurred with each infusion. Changes were similar, but slightly less marked, after pretreatment with propranolol. Thus, doses of hypertonic mannitol that are feasible in the clinical setting cause significant hemodynamic alterations in the intact animal, including a substantial direct inotropic effect on the heart. The increased contractile force of the left ventricle is not dependent on changes in sympathetic nervous activity or the Frank Starling mechanism.

UR - http://www.scopus.com/inward/record.url?scp=0015875471&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0015875471&partnerID=8YFLogxK

M3 - Chapter

VL - 225

SP - 132

EP - 137

BT - American Journal of Physiology

ER -