Cardiovascular risk factors associated with smaller brain volumes in regions identified as early predictors of cognitive decline

Rajiv N. Srinivasa, Heidi Rossetti, Mohit K. Gupta, Roger N Rosenberg, Myron F. Weiner, Ronald M Peshock, Roderick W McColl, Linda S Hynan, Richard T. Lucarelli, Kevin S. King

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Purpose: To determine in a large multiethnic cohort the cardiovascular and genetic risk factors associated with smaller volume in the hippocampus, precuneus, and posterior cingulate, and their association with preclinical deficits in cognitive performance in patients younger and older than 50 years. Materials and Methods: The institutional review board approved the study and all participants provided written informed consent. Eligible for this study were 1629 participants (700 men and 929 women; mean age, 50.0 years 6 10.2 [standard deviation]) drawn from the population-based Dallas Heart Study who underwent laboratory and clinical analysis in an initial baseline visit and approximately 7 years later underwent brain magnetic resonance imaging with automated volumetry and cognitive assessment with the Montreal Cognitive Assessment (MoCA). Regression analysis showed associations between risk factors and segmental volumes, and associations between these volumes with cognitive performance in participants younger and older than 50 years. Results: Lower hippocampal volume was associated with previous alcohol consumption (standardized estimate, 20.04; P = .039) and smoking (standardized estimate, 20.04; P = .048). Several risk factors correlated with lower total brain, posterior cingulate, and precuneus volumes. Higher total (standardized estimate, 0.06; P = .050), high-density lipoprotein (standardized estimate, 0.07; P = .003), and lowdensity lipoprotein (standardized estimate, 0.04; P = .037) cholesterol levels were associated with larger posterior cingulate volume, and higher triglyceride levels (standardized estimate, 0.06; P = .004) were associated with larger precuneus volume. Total MoCA score was associated with posterior cingulate volume (standardized estimate, 0.13; P = .001) in younger individuals and with hippocampal (standardized estimate, 0.06; P , .05) and precuneus (standardized estimate, 0.08; P , .023) volumes in older adults. Conclusion: Smaller volumes in specific brain regions considered to be early markers of dementia risk were associated with specific cardiovascular disease risk factors and cognitive deficits in a predominantly midlife multiethnic populationbased sample. Additionally, the risk factors most associated with these brain volumes differed in participants younger and older than 50 years, as did the association between brain volume and MoCA score.

Original languageEnglish (US)
Pages (from-to)198-204
Number of pages7
JournalRadiology
Volume278
Issue number1
DOIs
StatePublished - Jan 1 2016

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Parietal Lobe
Gyrus Cinguli
Brain
Research Ethics Committees
HDL Lipoproteins
Informed Consent
Alcohol Drinking
Lipoproteins
Dementia
Hippocampus
Triglycerides
Cardiovascular Diseases
Smoking
Cholesterol
Regression Analysis
Magnetic Resonance Imaging
Cognitive Dysfunction
Population

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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Cardiovascular risk factors associated with smaller brain volumes in regions identified as early predictors of cognitive decline. / Srinivasa, Rajiv N.; Rossetti, Heidi; Gupta, Mohit K.; Rosenberg, Roger N; Weiner, Myron F.; Peshock, Ronald M; McColl, Roderick W; Hynan, Linda S; Lucarelli, Richard T.; King, Kevin S.

In: Radiology, Vol. 278, No. 1, 01.01.2016, p. 198-204.

Research output: Contribution to journalArticle

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abstract = "Purpose: To determine in a large multiethnic cohort the cardiovascular and genetic risk factors associated with smaller volume in the hippocampus, precuneus, and posterior cingulate, and their association with preclinical deficits in cognitive performance in patients younger and older than 50 years. Materials and Methods: The institutional review board approved the study and all participants provided written informed consent. Eligible for this study were 1629 participants (700 men and 929 women; mean age, 50.0 years 6 10.2 [standard deviation]) drawn from the population-based Dallas Heart Study who underwent laboratory and clinical analysis in an initial baseline visit and approximately 7 years later underwent brain magnetic resonance imaging with automated volumetry and cognitive assessment with the Montreal Cognitive Assessment (MoCA). Regression analysis showed associations between risk factors and segmental volumes, and associations between these volumes with cognitive performance in participants younger and older than 50 years. Results: Lower hippocampal volume was associated with previous alcohol consumption (standardized estimate, 20.04; P = .039) and smoking (standardized estimate, 20.04; P = .048). Several risk factors correlated with lower total brain, posterior cingulate, and precuneus volumes. Higher total (standardized estimate, 0.06; P = .050), high-density lipoprotein (standardized estimate, 0.07; P = .003), and lowdensity lipoprotein (standardized estimate, 0.04; P = .037) cholesterol levels were associated with larger posterior cingulate volume, and higher triglyceride levels (standardized estimate, 0.06; P = .004) were associated with larger precuneus volume. Total MoCA score was associated with posterior cingulate volume (standardized estimate, 0.13; P = .001) in younger individuals and with hippocampal (standardized estimate, 0.06; P , .05) and precuneus (standardized estimate, 0.08; P , .023) volumes in older adults. Conclusion: Smaller volumes in specific brain regions considered to be early markers of dementia risk were associated with specific cardiovascular disease risk factors and cognitive deficits in a predominantly midlife multiethnic populationbased sample. Additionally, the risk factors most associated with these brain volumes differed in participants younger and older than 50 years, as did the association between brain volume and MoCA score.",
author = "Srinivasa, {Rajiv N.} and Heidi Rossetti and Gupta, {Mohit K.} and Rosenberg, {Roger N} and Weiner, {Myron F.} and Peshock, {Ronald M} and McColl, {Roderick W} and Hynan, {Linda S} and Lucarelli, {Richard T.} and King, {Kevin S.}",
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T1 - Cardiovascular risk factors associated with smaller brain volumes in regions identified as early predictors of cognitive decline

AU - Srinivasa, Rajiv N.

AU - Rossetti, Heidi

AU - Gupta, Mohit K.

AU - Rosenberg, Roger N

AU - Weiner, Myron F.

AU - Peshock, Ronald M

AU - McColl, Roderick W

AU - Hynan, Linda S

AU - Lucarelli, Richard T.

AU - King, Kevin S.

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N2 - Purpose: To determine in a large multiethnic cohort the cardiovascular and genetic risk factors associated with smaller volume in the hippocampus, precuneus, and posterior cingulate, and their association with preclinical deficits in cognitive performance in patients younger and older than 50 years. Materials and Methods: The institutional review board approved the study and all participants provided written informed consent. Eligible for this study were 1629 participants (700 men and 929 women; mean age, 50.0 years 6 10.2 [standard deviation]) drawn from the population-based Dallas Heart Study who underwent laboratory and clinical analysis in an initial baseline visit and approximately 7 years later underwent brain magnetic resonance imaging with automated volumetry and cognitive assessment with the Montreal Cognitive Assessment (MoCA). Regression analysis showed associations between risk factors and segmental volumes, and associations between these volumes with cognitive performance in participants younger and older than 50 years. Results: Lower hippocampal volume was associated with previous alcohol consumption (standardized estimate, 20.04; P = .039) and smoking (standardized estimate, 20.04; P = .048). Several risk factors correlated with lower total brain, posterior cingulate, and precuneus volumes. Higher total (standardized estimate, 0.06; P = .050), high-density lipoprotein (standardized estimate, 0.07; P = .003), and lowdensity lipoprotein (standardized estimate, 0.04; P = .037) cholesterol levels were associated with larger posterior cingulate volume, and higher triglyceride levels (standardized estimate, 0.06; P = .004) were associated with larger precuneus volume. Total MoCA score was associated with posterior cingulate volume (standardized estimate, 0.13; P = .001) in younger individuals and with hippocampal (standardized estimate, 0.06; P , .05) and precuneus (standardized estimate, 0.08; P , .023) volumes in older adults. Conclusion: Smaller volumes in specific brain regions considered to be early markers of dementia risk were associated with specific cardiovascular disease risk factors and cognitive deficits in a predominantly midlife multiethnic populationbased sample. Additionally, the risk factors most associated with these brain volumes differed in participants younger and older than 50 years, as did the association between brain volume and MoCA score.

AB - Purpose: To determine in a large multiethnic cohort the cardiovascular and genetic risk factors associated with smaller volume in the hippocampus, precuneus, and posterior cingulate, and their association with preclinical deficits in cognitive performance in patients younger and older than 50 years. Materials and Methods: The institutional review board approved the study and all participants provided written informed consent. Eligible for this study were 1629 participants (700 men and 929 women; mean age, 50.0 years 6 10.2 [standard deviation]) drawn from the population-based Dallas Heart Study who underwent laboratory and clinical analysis in an initial baseline visit and approximately 7 years later underwent brain magnetic resonance imaging with automated volumetry and cognitive assessment with the Montreal Cognitive Assessment (MoCA). Regression analysis showed associations between risk factors and segmental volumes, and associations between these volumes with cognitive performance in participants younger and older than 50 years. Results: Lower hippocampal volume was associated with previous alcohol consumption (standardized estimate, 20.04; P = .039) and smoking (standardized estimate, 20.04; P = .048). Several risk factors correlated with lower total brain, posterior cingulate, and precuneus volumes. Higher total (standardized estimate, 0.06; P = .050), high-density lipoprotein (standardized estimate, 0.07; P = .003), and lowdensity lipoprotein (standardized estimate, 0.04; P = .037) cholesterol levels were associated with larger posterior cingulate volume, and higher triglyceride levels (standardized estimate, 0.06; P = .004) were associated with larger precuneus volume. Total MoCA score was associated with posterior cingulate volume (standardized estimate, 0.13; P = .001) in younger individuals and with hippocampal (standardized estimate, 0.06; P , .05) and precuneus (standardized estimate, 0.08; P , .023) volumes in older adults. Conclusion: Smaller volumes in specific brain regions considered to be early markers of dementia risk were associated with specific cardiovascular disease risk factors and cognitive deficits in a predominantly midlife multiethnic populationbased sample. Additionally, the risk factors most associated with these brain volumes differed in participants younger and older than 50 years, as did the association between brain volume and MoCA score.

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