Case report: Refractory cryptosporidiosis after car t-cell therapy for lymphoma

Caitlin A. Trottier, Christina F. Yen, Grace Malvar, Jon Arnason, David E. Avigan, Carolyn D. Alonso

Research output: Contribution to journalArticlepeer-review

Abstract

Cryptosporidial diarrhea is uncommon in immunocompetent individuals, more often seen in severely immunocompromised patients. Severe refractory cases have been described in patients with HIV/AIDS before the advent of modern antiretroviral therapy due to an inability to mount an adequate cellular immune response. We describe an 85-year-old patient post–chimeric antigen receptor T-cell therapy relapsed lymphoma who developed refractory Cryptosporidium spp. diarrhea in the setting of persistent CD41 cytopenia. Despite receiving multiple antiparasitic agents, including failure of a prolonged course of nitazoxanide, the patient experienced persistent symptoms for 9 months with repeatedly positivity stool Cryptosporidium spp. direct fluorescent antibody (DFA) test. We highlight this case of refractory Cryptosporidium spp. and the importance of recognizing the pathogen in a non–HIV-infected immunosuppressed host.

Original languageEnglish (US)
Pages (from-to)651
Number of pages1
JournalAmerican Journal of Tropical Medicine and Hygiene
Volume105
Issue number3
DOIs
StatePublished - Sep 2021
Externally publishedYes

ASJC Scopus subject areas

  • Parasitology
  • Virology
  • Infectious Diseases

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