Case report: transverse myelitis associated with Epstein-Barr virus infection.

C. Caldas, E. Bernicker, A. D. Nogare, J. P. Luby

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Abstract

Transverse myelitis is a rare complication of Epstein-Barr virus (EBV) infection. This article describes a case of a previously healthy patient with a subacute transverse myelopathy. The cerebrospinal fluid showed lymphocytic pleocytosis and protein elevation. A magnetic resonance imaging scan demonstrated abnormal spinal cord signal intensity over several cervical and thoracic segments, suggesting the diagnosis of transverse myelitis. The patient was treated with high-dose corticosteroids and had a rapid improvement. Serologic studies for other viruses were negative; antibody tests indicated acute EBV infection. It is thought this represents a case of transverse myelitis associated with acute EBV infection. Although a few similar patients have been reported previously, this case is the first where EBV serology suggested the etiology at the time of diagnosis, when EBV antibody titers and polymerase-chain reaction for EBV DNA in the cerebrospinal fluid were performed, and when a magnetic resonance imaging scan was used for diagnosis and follow-up.

Original languageEnglish (US)
Pages (from-to)45-48
Number of pages4
JournalAmerican Journal of the Medical Sciences
Volume307
Issue number1
StatePublished - Jan 1994

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Transverse Myelitis
Epstein-Barr Virus Infections
Human Herpesvirus 4
Cerebrospinal Fluid
Magnetic Resonance Imaging
Antibodies
Spinal Cord Diseases
Leukocytosis
Serology
Viral Load
Spinal Cord
Adrenal Cortex Hormones
Thorax
Viruses
Polymerase Chain Reaction
DNA
Proteins

ASJC Scopus subject areas

  • Medicine(all)

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Case report : transverse myelitis associated with Epstein-Barr virus infection. / Caldas, C.; Bernicker, E.; Nogare, A. D.; Luby, J. P.

In: American Journal of the Medical Sciences, Vol. 307, No. 1, 01.1994, p. 45-48.

Research output: Contribution to journalArticle

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