Catalytic antibodies: Perusing combinatorial libraries

Bruce Posner, Jeffrey Smiley, Irene Lee, Stephen Benkovic

Research output: Contribution to journalArticle

27 Scopus citations

Abstract

Combinatorial libraries are a promising alternative for isolating catalytic antibodies produced by the immune system in response to the transition-state analog of a given reaction. Large, diverse panels of antibodies with high affinity for the transition-state analog can be isolated using screening or selection approaches. Furthermore, we have estimated that nucleotide sequences that bear close similarity to the sequence for a known catalytic antibody occur in combination at frequencies sufficient for their detection in such libraries.

Original languageEnglish (US)
Pages (from-to)145-150
Number of pages6
JournalTrends in biochemical sciences
Volume19
Issue number4
DOIs
StatePublished - Apr 1994

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology

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