Catechol-O-methyltransferase activity in erythrocytes of pregnant women with sickle cell disease before, during, and after transfusion and partial exchange transfusion

F. Gary Cunningham, Susan Rawlins, M. Linette Casey, Paul C. MacDonald

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

In the present investigation, we found that the catechol-O-methyltransferase (COMT) activity in erythrocytes of pregnant women with sickle cell disease was strikingly elevated compared with that in erythrocytes of men and pregnant and nonpregnant women. Moreover, the enzyme activity in erythrocytes remained high during and after transfusion or partial exchange transfusion even though the enzyme activity in donor cells was low. This finding is suggestive of the possibility that a factor(s) in plasma of persons with sickle cell disease activates erythrocyte COMT activity.

Original languageEnglish (US)
Pages (from-to)573-575
Number of pages3
JournalAmerican Journal of Obstetrics and Gynecology
Volume147
Issue number5
StatePublished - Nov 1 1983

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Catechol O-Methyltransferase
Sickle Cell Anemia
Pregnant Women
Erythrocytes
Enzymes
Tissue Donors

ASJC Scopus subject areas

  • Medicine(all)
  • Obstetrics and Gynecology

Cite this

Catechol-O-methyltransferase activity in erythrocytes of pregnant women with sickle cell disease before, during, and after transfusion and partial exchange transfusion. / Cunningham, F. Gary; Rawlins, Susan; Casey, M. Linette; MacDonald, Paul C.

In: American Journal of Obstetrics and Gynecology, Vol. 147, No. 5, 01.11.1983, p. 573-575.

Research output: Contribution to journalArticle

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