Catechol-O-methyltransferase activity in erythrocytes of pregnant women with sickle cell disease before, during, and after transfusion and partial exchange transfusion

F. Gary Cunningham, Susan Rawlins, M. Linette Casey, Paul C. MacDonald

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

In the present investigation, we found that the catechol-O-methyltransferase (COMT) activity in erythrocytes of pregnant women with sickle cell disease was strikingly elevated compared with that in erythrocytes of men and pregnant and nonpregnant women. Moreover, the enzyme activity in erythrocytes remained high during and after transfusion or partial exchange transfusion even though the enzyme activity in donor cells was low. This finding is suggestive of the possibility that a factor(s) in plasma of persons with sickle cell disease activates erythrocyte COMT activity.

Original languageEnglish (US)
Pages (from-to)573-575
Number of pages3
JournalAmerican journal of obstetrics and gynecology
Volume147
Issue number5
DOIs
StatePublished - Nov 1 1983

    Fingerprint

ASJC Scopus subject areas

  • Obstetrics and Gynecology

Cite this