Catechol-O-methyltransferase activity in erythrocytes of women taking oral contraceptive steroids

G. W. Bates; C. D. Edman; J. C. Porter; P. C. MacDonald

doi:10.1016/0002-9378(79)90020-6

Catechol-O-methyltransferase activity in erythrocytes of women taking oral contraceptive steroids

G. W. Bates, C. D. Edman, J. C. Porter, P. C. MacDonald

Obstetrics & Gynecology

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Abstract

The authors have measured catechol-O-methyltransferase (COMT) activity in erythrocytes (red blood cells, RBCs) obtained from 64 women taking oral contraceptive steroids and compared these values with those found in RBCs obtained from 73 women using nonsteroidal contraceptives. The COMT activity in the RBCs of women taking oral contraceptive steroids and of women not taking contraceptive steroids was 9.1±0.28 (mean and standard error) and 8.8±0.26 nmoles 2-methoxyestrone x ml^-1 RBC x hr^-1, respectively. This difference in the COMT activity in RBCs from these two groups of women was not statistically significant. This finding differs from that of others who found that COMT activity in RBCs of women taking oral contraceptive steroids was greater than that of women not taking such drugs.

Original language	English (US)
Pages (from-to)	691-693
Number of pages	3
Journal	American journal of obstetrics and gynecology
Volume	133
Issue number	6
DOIs	https://doi.org/10.1016/0002-9378(79)90020-6
State	Published - 1979

ASJC Scopus subject areas

Obstetrics and Gynecology

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10.1016/0002-9378(79)90020-6

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@article{0b6f66b1ab224d02be83426ae1d5d736,

title = "Catechol-O-methyltransferase activity in erythrocytes of women taking oral contraceptive steroids",

abstract = "The authors have measured catechol-O-methyltransferase (COMT) activity in erythrocytes (red blood cells, RBCs) obtained from 64 women taking oral contraceptive steroids and compared these values with those found in RBCs obtained from 73 women using nonsteroidal contraceptives. The COMT activity in the RBCs of women taking oral contraceptive steroids and of women not taking contraceptive steroids was 9.1±0.28 (mean and standard error) and 8.8±0.26 nmoles 2-methoxyestrone x ml-1 RBC x hr-1, respectively. This difference in the COMT activity in RBCs from these two groups of women was not statistically significant. This finding differs from that of others who found that COMT activity in RBCs of women taking oral contraceptive steroids was greater than that of women not taking such drugs.",

author = "Bates, {G. W.} and Edman, {C. D.} and Porter, {J. C.} and MacDonald, {P. C.}",

note = "Funding Information: From the Cecil H. and Ida Green Center for Reproductive Biology Sciences and the Department of Obstetrics and Gynecology of Tht University of Texas Southtwstern Medical School. Supported, in part, by United States Public Health Sen•irf Grant> AM-06912 arui AG-00306.",

year = "1979",

doi = "10.1016/0002-9378(79)90020-6",

language = "English (US)",

volume = "133",

pages = "691--693",

journal = "American journal of obstetrics and gynecology",

issn = "0002-9378",

publisher = "Mosby Inc.",

number = "6",

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TY - JOUR

T1 - Catechol-O-methyltransferase activity in erythrocytes of women taking oral contraceptive steroids

AU - Bates, G. W.

AU - Edman, C. D.

AU - Porter, J. C.

AU - MacDonald, P. C.

N1 - Funding Information: From the Cecil H. and Ida Green Center for Reproductive Biology Sciences and the Department of Obstetrics and Gynecology of Tht University of Texas Southtwstern Medical School. Supported, in part, by United States Public Health Sen•irf Grant> AM-06912 arui AG-00306.

PY - 1979

Y1 - 1979

N2 - The authors have measured catechol-O-methyltransferase (COMT) activity in erythrocytes (red blood cells, RBCs) obtained from 64 women taking oral contraceptive steroids and compared these values with those found in RBCs obtained from 73 women using nonsteroidal contraceptives. The COMT activity in the RBCs of women taking oral contraceptive steroids and of women not taking contraceptive steroids was 9.1±0.28 (mean and standard error) and 8.8±0.26 nmoles 2-methoxyestrone x ml-1 RBC x hr-1, respectively. This difference in the COMT activity in RBCs from these two groups of women was not statistically significant. This finding differs from that of others who found that COMT activity in RBCs of women taking oral contraceptive steroids was greater than that of women not taking such drugs.

AB - The authors have measured catechol-O-methyltransferase (COMT) activity in erythrocytes (red blood cells, RBCs) obtained from 64 women taking oral contraceptive steroids and compared these values with those found in RBCs obtained from 73 women using nonsteroidal contraceptives. The COMT activity in the RBCs of women taking oral contraceptive steroids and of women not taking contraceptive steroids was 9.1±0.28 (mean and standard error) and 8.8±0.26 nmoles 2-methoxyestrone x ml-1 RBC x hr-1, respectively. This difference in the COMT activity in RBCs from these two groups of women was not statistically significant. This finding differs from that of others who found that COMT activity in RBCs of women taking oral contraceptive steroids was greater than that of women not taking such drugs.

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U2 - 10.1016/0002-9378(79)90020-6

DO - 10.1016/0002-9378(79)90020-6

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AN - SCOPUS:0018380811

SN - 0002-9378

VL - 133

SP - 691

EP - 693

JO - American journal of obstetrics and gynecology

JF - American journal of obstetrics and gynecology

IS - 6

ER -

Catechol-O-methyltransferase activity in erythrocytes of women taking oral contraceptive steroids

Abstract

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