Catheter-related bloodstream infections in patients on emergent hemodialysis

Christian A. Rojas-Moreno, Daniel Spiegel, Venkata Yalamanchili, Elizabeth Kuo, Henry Quinones, Pranavi V. Sreeramoju, James P. Luby

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

objective. This study had 2 objectives: (1) to describe the epidemiology of catheter-related bloodstream infections (CRBSI) in patients with end-stage renal disease (ESRD) who have no access to scheduled dialysis and (2) to evaluate whether a positive culture of the heparin-lock solution is associated with subsequent development of bacteremia. design. Retrospective observational cohort design for objective 1; and prospective cohort design for objective 2. setting and participants. The study was conducted in a 770-bed public academic tertiary hospital in Dallas, Texas. The participants were patients with ESRD undergoing scheduled or emergent hemodialysis. methods. We reviewed the records of 147 patients who received hemodialysis between January 2011 and May 2011 and evaluated the rate of CRBSI in the previous 5 years. For the prospective study, we cultured the catheter heparin-lock solution in 62 consecutive patients between June 2012 and August 2012 and evaluated the incidence of CRBSI at 6 months. results. Of the 147 patients on emergent hemodialysis, 125 had a tunneled catheter, with a CRBSI rate of 2.61 per 1,000 catheter days. The predominant organisms were Gram-negative rods (GNR). In the prospective study, we found that the dialysis catheter was colonized more frequently in patients on emergent hemodialysis than in those on scheduled hemodialysis. Colonization with GNR or Staphylococcus aureus was associated with subsequent CRBSI at 6 months follow-up. conclusions. Patients undergoing emergent hemodialysis via tunneled catheter are predisposed to Gram-negative CRBSI. Culturing the heparin-lock solution may predict subsequent episodes of CRBSI if it shows colonization with GNR or Staphylococcus aureus. Prevention approaches in this population need to be studied further.

Original languageEnglish (US)
Pages (from-to)301-305
Number of pages5
JournalInfection Control and Hospital Epidemiology
Volume37
Issue number3
DOIs
StatePublished - Dec 7 2015

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Catheter-Related Infections
Renal Dialysis
Catheters
Heparin
Chronic Kidney Failure
Staphylococcus aureus
Dialysis
Prospective Studies
Bacteremia
Tertiary Care Centers
Epidemiology
Incidence
Population

ASJC Scopus subject areas

  • Microbiology (medical)
  • Epidemiology
  • Infectious Diseases

Cite this

Catheter-related bloodstream infections in patients on emergent hemodialysis. / Rojas-Moreno, Christian A.; Spiegel, Daniel; Yalamanchili, Venkata; Kuo, Elizabeth; Quinones, Henry; Sreeramoju, Pranavi V.; Luby, James P.

In: Infection Control and Hospital Epidemiology, Vol. 37, No. 3, 07.12.2015, p. 301-305.

Research output: Contribution to journalArticle

Rojas-Moreno, Christian A. ; Spiegel, Daniel ; Yalamanchili, Venkata ; Kuo, Elizabeth ; Quinones, Henry ; Sreeramoju, Pranavi V. ; Luby, James P. / Catheter-related bloodstream infections in patients on emergent hemodialysis. In: Infection Control and Hospital Epidemiology. 2015 ; Vol. 37, No. 3. pp. 301-305.
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