Cation exchange separation of 61Cu2+ from natCo targets and preparation of 61Cu-DOTA-HSA as a blood pool agent

Guiyang Hao, Toshimitsu Fukumura, Ryuji Nakao, Hisashi Suzuki, Ferenc Szelecsényi, Zoltan Kovács, Kazutoshi Suzuki

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8 Scopus citations

Abstract

An improved method for isolation of 61Cu2+ from a natCo target using cation exchange was developed. 61Cu2+ was eluted from a cation exchange resin column by 0.2 M HCl with 90% acetone, while Co2+ remained on the column. The whole separation process was completed within 50 min at more than 72% yield. The Co2+ impurity level in 61Cu2+ solution was reduced to less than 0.1 ppm. Highly pure 61Cu2+ solution was then applied to prepare 61Cu-1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA)-human serum albumin (HSA) which showed good blood pool imaging properties.

Original languageEnglish (US)
Pages (from-to)511-515
Number of pages5
JournalApplied Radiation and Isotopes
Volume67
Issue number4
DOIs
StatePublished - Apr 1 2009

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Keywords

  • Cation exchange resin
  • Cu
  • DOTA
  • HSA
  • Isolation

ASJC Scopus subject areas

  • Radiation

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