Cations decrease specific [3H]-spiroperidol binding in human prefrontal cortex

Emina H. Huang, John M. Pickett, Joel D. Siegal, Anne C. Andorn

Research output: Contribution to journalArticlepeer-review

Abstract

Ligand binding at many physiologically relevant receptors is regulated by divalent cations. To determine whether [3H]-spiroperidol binding sites in prefrontal cortex might be physiologically relevant receptors, we examined the effect of ions on the binding of this ligand in postmortem human prefrontal cortex. Our results indicate that several cations decreased [3H]-spiroperidol binding in a dose-dependent fashion. Of these, Cd++ and Zn++ were the most able to decrease [3H]-spiroperidol binding with IC50 of 5.5.5 +/- 2.4 × 10-6M and 5.6 +/- 1.1 × 10-5M respectively. These findings indicate that [3H]-spiroperidol may bind at physiologically relevant receptors in human prefrontal cortex.

Original languageEnglish (US)
Pages (from-to)1369-1373
Number of pages5
JournalLife Sciences
Volume38
Issue number15
DOIs
StatePublished - Apr 14 1986
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

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