CATP is a critical component of the Neurospora circadian clock by regulating the nucleosome occupancy rhythm at the frequency locus

Joonseok Cha, Mian Zhou, Yi Liu

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Rhythmic frq transcription is essential for the function of the Neurospora circadian clock. Here we show that there is a circadian histone occupancy rhythm at the frq promoter that is regulated by FREQUENCY (FRQ). Using a combination of forward genetics and genome sequencing, we identify Clock ATPase (CATP) as an essential clock component. Our results demonstrate that CATP associates with the frq locus and other WCC target genes and promotes histone removal at these loci to allow circadian gene transcription. These results indicate that the rhythmic control of histone occupancy at clock genes is critical for circadian clock function.

Original languageEnglish (US)
Pages (from-to)923-930
Number of pages8
JournalEMBO Reports
Volume14
Issue number10
DOIs
StatePublished - Oct 2013

Fingerprint

Neurospora
Circadian Clocks
Nucleosomes
Histones
Adenosine Triphosphatases
Clocks
Genes
Transcription
Genome

ASJC Scopus subject areas

  • Genetics
  • Molecular Biology
  • Biochemistry

Cite this

CATP is a critical component of the Neurospora circadian clock by regulating the nucleosome occupancy rhythm at the frequency locus. / Cha, Joonseok; Zhou, Mian; Liu, Yi.

In: EMBO Reports, Vol. 14, No. 10, 10.2013, p. 923-930.

Research output: Contribution to journalArticle

@article{5129eb21ca02484c826044b10f35b9d5,
title = "CATP is a critical component of the Neurospora circadian clock by regulating the nucleosome occupancy rhythm at the frequency locus",
abstract = "Rhythmic frq transcription is essential for the function of the Neurospora circadian clock. Here we show that there is a circadian histone occupancy rhythm at the frq promoter that is regulated by FREQUENCY (FRQ). Using a combination of forward genetics and genome sequencing, we identify Clock ATPase (CATP) as an essential clock component. Our results demonstrate that CATP associates with the frq locus and other WCC target genes and promotes histone removal at these loci to allow circadian gene transcription. These results indicate that the rhythmic control of histone occupancy at clock genes is critical for circadian clock function.",
author = "Joonseok Cha and Mian Zhou and Yi Liu",
year = "2013",
month = "10",
doi = "10.1038/embor.2013.131",
language = "English (US)",
volume = "14",
pages = "923--930",
journal = "EMBO Reports",
issn = "1469-221X",
publisher = "Nature Publishing Group",
number = "10",

}

TY - JOUR

T1 - CATP is a critical component of the Neurospora circadian clock by regulating the nucleosome occupancy rhythm at the frequency locus

AU - Cha, Joonseok

AU - Zhou, Mian

AU - Liu, Yi

PY - 2013/10

Y1 - 2013/10

N2 - Rhythmic frq transcription is essential for the function of the Neurospora circadian clock. Here we show that there is a circadian histone occupancy rhythm at the frq promoter that is regulated by FREQUENCY (FRQ). Using a combination of forward genetics and genome sequencing, we identify Clock ATPase (CATP) as an essential clock component. Our results demonstrate that CATP associates with the frq locus and other WCC target genes and promotes histone removal at these loci to allow circadian gene transcription. These results indicate that the rhythmic control of histone occupancy at clock genes is critical for circadian clock function.

AB - Rhythmic frq transcription is essential for the function of the Neurospora circadian clock. Here we show that there is a circadian histone occupancy rhythm at the frq promoter that is regulated by FREQUENCY (FRQ). Using a combination of forward genetics and genome sequencing, we identify Clock ATPase (CATP) as an essential clock component. Our results demonstrate that CATP associates with the frq locus and other WCC target genes and promotes histone removal at these loci to allow circadian gene transcription. These results indicate that the rhythmic control of histone occupancy at clock genes is critical for circadian clock function.

UR - http://www.scopus.com/inward/record.url?scp=84885330642&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84885330642&partnerID=8YFLogxK

U2 - 10.1038/embor.2013.131

DO - 10.1038/embor.2013.131

M3 - Article

VL - 14

SP - 923

EP - 930

JO - EMBO Reports

JF - EMBO Reports

SN - 1469-221X

IS - 10

ER -