Caveolae and human disease: functional roles in transcytosis, potocytosis, signalling and cell polarity

Michael P. Lisanti, Philipp E. Scherer, ZhaoLan Tang, Eric Kübler, Anthony J. Koleske, Massimo Sargiacomo

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

Caveolae are 50-100 nm invaginations that represent a sub-compartment of the plasma membrane. Recent studies have implicated these membranous structures in: (1) transcytosis of macromolecules (such as LDL and AGEs) across capillary endothelial cells; (2) potocytic uptake of small molecules via GPI-linked receptors coupled with an unknown anion transport protein; (3) certain transmembrane signalling events; and (4) polarized trafficking of GPI-linked proteins in epithelial cells. Biochemical isolation and characterization of these domains reveals the molecular components that could perform these diverse functions: scavenger receptors for oxidized LDL and AGEs, namely CD 36 and RAGE, respectively (transcytosis); plasma membrane porin (potocytosis); heterotrimeric G-proteins and Src-like kinases (signalling); and Rap GTPases (cell polarity). As such, these findings have clear implications for understanding the molecular pathogenesis of several human diseases - including atherosclerosis, diabetic vascular complications, and cancerous cell transformations.

Original languageEnglish (US)
Pages (from-to)47-58
Number of pages12
JournalSeminars in Developmental Biology
Volume6
Issue number1
DOIs
StatePublished - 1995

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Transcytosis
Caveolae
Cell Polarity
Anion Transport Proteins
GPI-Linked Proteins
Cell Membrane
Heterotrimeric GTP-Binding Proteins
Scavenger Receptors
Diabetic Angiopathies
Porins
src-Family Kinases
GTP Phosphohydrolases
Atherosclerosis
Endothelial Cells
Epithelial Cells
oxidized low density lipoprotein

Keywords

  • caveolin
  • GPI-linked proteins
  • plasma membrane porin
  • Rap GTPases
  • scavenger receptors

Cite this

Caveolae and human disease : functional roles in transcytosis, potocytosis, signalling and cell polarity. / Lisanti, Michael P.; Scherer, Philipp E.; Tang, ZhaoLan; Kübler, Eric; Koleske, Anthony J.; Sargiacomo, Massimo.

In: Seminars in Developmental Biology, Vol. 6, No. 1, 1995, p. 47-58.

Research output: Contribution to journalArticle

Lisanti, Michael P. ; Scherer, Philipp E. ; Tang, ZhaoLan ; Kübler, Eric ; Koleske, Anthony J. ; Sargiacomo, Massimo. / Caveolae and human disease : functional roles in transcytosis, potocytosis, signalling and cell polarity. In: Seminars in Developmental Biology. 1995 ; Vol. 6, No. 1. pp. 47-58.
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