TY - JOUR
T1 - Caveolae, caveolin and caveolin-rich membrane domains
T2 - a signalling hypothesis
AU - Lisanti, Michael P.
AU - Scherer, Philipp E.
AU - Tang, ZhaoLan
AU - Sargiacomo, Massimo
PY - 1994/7
Y1 - 1994/7
N2 - Caveolae, 50-100 nm invaginations that represent a subcompartment of the plasma membrane, have been known for many years, but their exact roles remain uncertain. The findings that the caveola coat protein caveolin is a v-Src substrate and that G-protein-coupled receptors are present in caveolae have suggested a relationship between caveolae, caveolin and transmembrane signalling. The recent isolation of caveolin-rich membrane domains in which caveolin exists as a hetero-oligomeric complex with integral membrane proteins and known cytoplasmic signalling molecules provides support for this hypothesis. Compartmentalization of certain signalling molecules within caveolae could allow efficient and rapid coupling of activated receptors to more than one effector system.
AB - Caveolae, 50-100 nm invaginations that represent a subcompartment of the plasma membrane, have been known for many years, but their exact roles remain uncertain. The findings that the caveola coat protein caveolin is a v-Src substrate and that G-protein-coupled receptors are present in caveolae have suggested a relationship between caveolae, caveolin and transmembrane signalling. The recent isolation of caveolin-rich membrane domains in which caveolin exists as a hetero-oligomeric complex with integral membrane proteins and known cytoplasmic signalling molecules provides support for this hypothesis. Compartmentalization of certain signalling molecules within caveolae could allow efficient and rapid coupling of activated receptors to more than one effector system.
UR - http://www.scopus.com/inward/record.url?scp=0028285191&partnerID=8YFLogxK
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U2 - 10.1016/0962-8924(94)90114-7
DO - 10.1016/0962-8924(94)90114-7
M3 - Article
C2 - 14731661
AN - SCOPUS:0028285191
SN - 0962-8924
VL - 4
SP - 231
EP - 235
JO - Trends in Cell Biology
JF - Trends in Cell Biology
IS - 7
ER -