Caveolin-1 as a pathophysiological factor and target in psoriasis

Ilja L. Kruglikov, Philipp E Scherer

Research output: Contribution to journalReview article

Abstract

Low expression of caveolin-1 (Cav-1) is typical in psoriatic lesions and overexpression of Cav-1 leads to a reduction of inflammation and suppression of epidermal hyperproliferation, thus ameliorating these two well-known hallmarks of psoriasis. At the same time, the interfacial layers of the white adipose tissue (WAT) adjacent to psoriatic lesions demonstrate much higher stiffness, which also points to a modification of Cav-1 expression in this tissue. These processes are connected with each other and regulated via exosomal exchange. Here we discuss the role of Cav-1 expression in inflammatory and hyperproliferative processes and analyze the ways to provide spatially different modulation of Cav-1 expression in the skin and WAT. Such modulation can be induced by different pharmacological and physical factors. These include application of mechanical stress and supra-physiological temperatures. Cav-1 should therefore be considered as an important target in treatment of psoriasis.

Original languageEnglish (US)
Article number4
Journalnpj Aging and Mechanisms of Disease
Volume5
Issue number1
DOIs
StatePublished - Dec 1 2019

Fingerprint

Caveolin 1
Psoriasis
White Adipose Tissue
Mechanical Stress
Pharmacology
Inflammation
Skin
Temperature

ASJC Scopus subject areas

  • Aging
  • Geriatrics and Gerontology

Cite this

Caveolin-1 as a pathophysiological factor and target in psoriasis. / Kruglikov, Ilja L.; Scherer, Philipp E.

In: npj Aging and Mechanisms of Disease, Vol. 5, No. 1, 4, 01.12.2019.

Research output: Contribution to journalReview article

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