Caveolin-1 as a possible target in the treatment for acne

Ilja L. Kruglikov, Philipp E. Scherer

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

Expression of caveolin-1 (Cav-1) is an important pathophysiological factor in acne. Cav-1 strongly interacts with such well-recognized etiopathogenic factors such as hyperseborrhea, follicular hyperkeratinization and pathogenicity of Cutibacterium acnes. Cav-1 is a strong negative regulator of transforming growth factor beta (TGF-β) expression. It acts as a critical determinant of autophagy, which is significantly induced in acne lesions through C. acnes and by absorption of fatty acids. Cav-1 also demonstrates different correlations with the development of innate immunity. We propose that normalization of Cav-1 expression can serve as a target in anti-acne therapy.

Original languageEnglish (US)
Pages (from-to)177-183
Number of pages7
JournalExperimental Dermatology
Volume29
Issue number2
DOIs
StatePublished - Feb 1 2020

Keywords

  • acne
  • autophagy
  • C. acnes
  • caveolin
  • follicular hyperkeratinization
  • hyperseborrhea
  • innate immunity
  • pathophysiology

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Dermatology

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