TY - JOUR
T1 - Caveolin-1 as a target in prevention and treatment of hypertrophic scarring
AU - Kruglikov, Ilja L.
AU - Scherer, Philipp E.
PY - 2019/12/1
Y1 - 2019/12/1
N2 - Reduced expression of caveolin-1 (Cav-1) is an important pathogenic factor in hypertrophic scarring (HTS). Such a reduction can be found in connection with the main known risk factors for HTS, including dark skin, female gender, young age, burn site and severity of the injury. The degree of overexpression of Cav-1 associated with different therapeutic options for HTS correlates with clinical improvements in HTS. This makes endo- or exogenous induction of Cav-1 not only an important therapeutic target for HTS, but also highlights its use as a preventive target to reduce or avoid HTS formation.
AB - Reduced expression of caveolin-1 (Cav-1) is an important pathogenic factor in hypertrophic scarring (HTS). Such a reduction can be found in connection with the main known risk factors for HTS, including dark skin, female gender, young age, burn site and severity of the injury. The degree of overexpression of Cav-1 associated with different therapeutic options for HTS correlates with clinical improvements in HTS. This makes endo- or exogenous induction of Cav-1 not only an important therapeutic target for HTS, but also highlights its use as a preventive target to reduce or avoid HTS formation.
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U2 - 10.1038/s41536-019-0071-x
DO - 10.1038/s41536-019-0071-x
M3 - Article
C2 - 31044089
AN - SCOPUS:85071972498
VL - 4
JO - npj Regenerative Medicine
JF - npj Regenerative Medicine
SN - 2057-3995
IS - 1
M1 - 9
ER -