Caveolin-1 as a target in prevention and treatment of hypertrophic scarring

Ilja L. Kruglikov, Philipp E. Scherer

Research output: Contribution to journalArticlepeer-review

8 Scopus citations

Abstract

Reduced expression of caveolin-1 (Cav-1) is an important pathogenic factor in hypertrophic scarring (HTS). Such a reduction can be found in connection with the main known risk factors for HTS, including dark skin, female gender, young age, burn site and severity of the injury. The degree of overexpression of Cav-1 associated with different therapeutic options for HTS correlates with clinical improvements in HTS. This makes endo- or exogenous induction of Cav-1 not only an important therapeutic target for HTS, but also highlights its use as a preventive target to reduce or avoid HTS formation.

Original languageEnglish (US)
Article number9
Journalnpj Regenerative Medicine
Volume4
Issue number1
DOIs
StatePublished - Dec 1 2019

ASJC Scopus subject areas

  • Biomedical Engineering
  • Cell Biology
  • Developmental Biology
  • Medicine (miscellaneous)

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