Caveolin-1 in skin aging – From innocent bystander to major contributor

Ilja L. Kruglikov, Zhuzhen Zhang, Philipp E. Scherer

Research output: Contribution to journalReview article

4 Scopus citations

Abstract

Caveolin-1 (Cav-1) appears to be both a pathophysiological contributor and a target in different inflammatory and hyperproliferative skin conditions as well as in skin aging. Skin fibroblasts demonstrate an up-regulation of Cav-1 expression both in chronological and UV-induced aging, and such an up-regulation was observed both in vitro and in vivo. Typical alterations in aging skin involve a reduction of the dermis thickness, a significant expansion of the dermal white adipose tissue as well as modifications of the content and distribution of hyaluronan, impairment of autophagic flux, a reduction of collagen expression and an increase in tissue inflammation. All of these phenomena can be connected with changes in Cav-1 expression in the aging skin. Modified expression of Cav-1 can also significantly influence the mechanical properties of individual skin layers, thus changing the total mechanical stability of the layered composite skin/WAT, leading to typical structural modifications of the skin surface in the aging skin. Selective reduction of Cav-1 expression has the potential to exert anti-aging effects on the skin.

Original languageEnglish (US)
Article number100959
JournalAgeing Research Reviews
Volume55
DOIs
StatePublished - Nov 2019

Keywords

  • Caveolin-1
  • Collagen
  • Dermal-epidermal junction
  • Dermal-hypodermal junction
  • Hyaluronan
  • Inflammation
  • Skin aging
  • TGF-β

ASJC Scopus subject areas

  • Biotechnology
  • Biochemistry
  • Aging
  • Molecular Biology
  • Neurology

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