Caveolin as a universal target in dermatology

Ilja L. Kruglikov, Philipp E. Scherer

Research output: Contribution to journalReview article

Abstract

Caveolin‐1 is strongly expressed in different dermal and subdermal cells and physically interacts with signaling molecules and receptors, among them with transforming growth factor beta (TGF‐β), matrix metalloproteinases, heat shock proteins, toll‐like and glucocorticoid receptors. It should therefore be heavily involved in the regulation of cellular signaling in various hyperproliferative and inflammatory skin conditions. We provide an overview of the role of the caveolin‐1 expression in different hyperproliferative and inflammatory skin diseases and discuss its possible active involvement in the therapeutic effects of different well‐known drugs widely applied in dermatology. We also discuss the possible role of caveolin expression in development of the drug resistance in dermatology. Caveolin‐1 is not only an important pathophysiological factor in different hyperproliferative and inflammatory dermatological conditions, but can also serve as a target for their treatment. Targeted regulation of caveolin is likely to serve as a new treatment strategy in dermatology.

Original languageEnglish (US)
Article number80
JournalInternational journal of molecular sciences
Volume21
Issue number1
DOIs
StatePublished - Jan 1 2020

Keywords

  • Caveolin‐1
  • Dermatology
  • Pathophysiology
  • Psoriasis
  • Scarring
  • Skin aging
  • Target
  • Wound healing

ASJC Scopus subject areas

  • Catalysis
  • Molecular Biology
  • Spectroscopy
  • Computer Science Applications
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry

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