Cavin-3 dictates the balance between ERK and Akt signaling

Victor J. Hernandez, Jian Weng, Peter Ly, Shanica Pompey, Hongyun Dong, Lopa Mishra, Margaret Schwarz, Richard G W Anderson, Peter Michaely

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

Cavin-3 is a tumor suppressor protein of unknown function. Using both in vivo and in vitro approaches, we show that cavin-3 dictates the balance between ERK and Akt signaling. Loss of cavin-3 increases Akt signaling at the expense of ERK, while gain of cavin-3 increases ERK signaling at the expense Akt. Cavin-3 facilitates signal transduction to ERK by anchoring caveolae to the membrane skeleton of the plasma membrane via myosin-1c. Caveolae are lipid raft specializations that contain an ERK activation module and loss of the cavin-3 linkage reduces the abundance of caveolae, thereby separating this ERK activation module from signaling receptors. Loss of cavin-3 promotes Akt signaling through suppression of EGR1 and PTEN. The in vitro consequences of the loss of cavin-3 include induction of Warburg metabolism (aerobic glycolysis), accelerated cell proliferation, and resistance to apoptosis. The in vivo consequences of cavin-3 knockout are increased lactate production and cachexia.

Original languageEnglish (US)
Article numbere00905
JournaleLife
Volume2013
Issue number2
DOIs
StatePublished - Sep 24 2013

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Caveolae
Chemical activation
Tumor Suppressor Proteins
Caviner
Signal transduction
Cachexia
Cell proliferation
Glycolysis
Cell membranes
Myosins
Metabolism
Skeleton
Lactic Acid
Signal Transduction
Cell Proliferation
Cell Membrane
Apoptosis
Membranes
Lipids
In Vitro Techniques

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)
  • Medicine(all)
  • Neuroscience(all)

Cite this

Hernandez, V. J., Weng, J., Ly, P., Pompey, S., Dong, H., Mishra, L., ... Michaely, P. (2013). Cavin-3 dictates the balance between ERK and Akt signaling. eLife, 2013(2), [e00905]. https://doi.org/10.7554/eLife.00905

Cavin-3 dictates the balance between ERK and Akt signaling. / Hernandez, Victor J.; Weng, Jian; Ly, Peter; Pompey, Shanica; Dong, Hongyun; Mishra, Lopa; Schwarz, Margaret; Anderson, Richard G W; Michaely, Peter.

In: eLife, Vol. 2013, No. 2, e00905, 24.09.2013.

Research output: Contribution to journalArticle

Hernandez, VJ, Weng, J, Ly, P, Pompey, S, Dong, H, Mishra, L, Schwarz, M, Anderson, RGW & Michaely, P 2013, 'Cavin-3 dictates the balance between ERK and Akt signaling', eLife, vol. 2013, no. 2, e00905. https://doi.org/10.7554/eLife.00905
Hernandez VJ, Weng J, Ly P, Pompey S, Dong H, Mishra L et al. Cavin-3 dictates the balance between ERK and Akt signaling. eLife. 2013 Sep 24;2013(2). e00905. https://doi.org/10.7554/eLife.00905
Hernandez, Victor J. ; Weng, Jian ; Ly, Peter ; Pompey, Shanica ; Dong, Hongyun ; Mishra, Lopa ; Schwarz, Margaret ; Anderson, Richard G W ; Michaely, Peter. / Cavin-3 dictates the balance between ERK and Akt signaling. In: eLife. 2013 ; Vol. 2013, No. 2.
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