Cavity formation before stable hydrogen bonding in the folding of a β- clam protein

P. L. Clark, Zhi-Ping Liu, Jose Rizo-Rey, L. M. Gierasch

Research output: Contribution to journalArticle

54 Scopus citations


The time course of folding of a small β-sheet protein reveals formation of a central ligand binding cavity before the consolidation of the native hydrogen bonding network. These results suggest that side chain interactions and not stable hydrogen bonding determine the β-sheet architecture and play crucial roles in the overall chain topology.

Original languageEnglish (US)
Pages (from-to)883-886
Number of pages4
JournalNature Structural Biology
Issue number11
StatePublished - Nov 19 1997


ASJC Scopus subject areas

  • Structural Biology
  • Biochemistry
  • Genetics

Cite this