Cavity formation before stable hydrogen bonding in the folding of a β- clam protein

P. L. Clark, Zhi-Ping Liu, Jose Rizo-Rey, L. M. Gierasch

Research output: Contribution to journalArticle

54 Scopus citations

Abstract

The time course of folding of a small β-sheet protein reveals formation of a central ligand binding cavity before the consolidation of the native hydrogen bonding network. These results suggest that side chain interactions and not stable hydrogen bonding determine the β-sheet architecture and play crucial roles in the overall chain topology.

Original languageEnglish (US)
Pages (from-to)883-886
Number of pages4
JournalNature Structural Biology
Volume4
Issue number11
DOIs
StatePublished - Nov 19 1997

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ASJC Scopus subject areas

  • Structural Biology
  • Biochemistry
  • Genetics

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