Cavity formation before stable hydrogen bonding in the folding of a β- clam protein

P. L. Clark; Zhi-Ping Liu; Jose Rizo-Rey; L. M. Gierasch

doi:10.1038/nsb1197-883

Cavity formation before stable hydrogen bonding in the folding of a β- clam protein

P. L. Clark, Zhi-Ping Liu, Jose Rizo-Rey, L. M. Gierasch

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55 Scopus citations

Abstract

The time course of folding of a small β-sheet protein reveals formation of a central ligand binding cavity before the consolidation of the native hydrogen bonding network. These results suggest that side chain interactions and not stable hydrogen bonding determine the β-sheet architecture and play crucial roles in the overall chain topology.

Original language	English (US)
Pages (from-to)	883-886
Number of pages	4
Journal	Nature Structural Biology
Volume	4
Issue number	11
DOIs	https://doi.org/10.1038/nsb1197-883
State	Published - 1997

ASJC Scopus subject areas

Structural Biology
Biochemistry
Genetics

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title = "Cavity formation before stable hydrogen bonding in the folding of a β- clam protein",

abstract = "The time course of folding of a small β-sheet protein reveals formation of a central ligand binding cavity before the consolidation of the native hydrogen bonding network. These results suggest that side chain interactions and not stable hydrogen bonding determine the β-sheet architecture and play crucial roles in the overall chain topology.",

author = "Clark, {P. L.} and Zhi-Ping Liu and Jose Rizo-Rey and Gierasch, {L. M.}",

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PY - 1997

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AB - The time course of folding of a small β-sheet protein reveals formation of a central ligand binding cavity before the consolidation of the native hydrogen bonding network. These results suggest that side chain interactions and not stable hydrogen bonding determine the β-sheet architecture and play crucial roles in the overall chain topology.

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Cavity formation before stable hydrogen bonding in the folding of a β- clam protein

Abstract

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