Cbl-b and itch: Key regulators of peripheral T-cell tolerance

K. Poojary Venuprasad

doi:10.1158/0008-5472.CAN-09-4076

Cbl-b and itch: Key regulators of peripheral T-cell tolerance

K. Poojary Venuprasad

Research output: Contribution to journal › Review article › peer-review

35 Scopus citations

Abstract

E3 ligases Cbl-b and Itch have emerged as dominant "tolerogenic" regulators of T cells because their deficiency results in severe autoimmune diseases. Cbl-b and Itch ligase activity regulate T-cell anergy and development of Foxp3+ regulatory T cells (Treg) in the periphery by modulating key components of T-cell receptor (TCR) and transforming growth factor-β (TGF-β) signaling. Manipulation of Cbl-b and Itch activities may provide unique opportunities to develop future therapies for immune disorders such as autoimmunity and cancer.

Original language	English (US)
Pages (from-to)	3009-3012
Number of pages	4
Journal	Cancer research
Volume	70
Issue number	8
DOIs	https://doi.org/10.1158/0008-5472.CAN-09-4076
State	Published - Apr 15 2010
Externally published	Yes

ASJC Scopus subject areas

Oncology
Cancer Research

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10.1158/0008-5472.CAN-09-4076

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AB - E3 ligases Cbl-b and Itch have emerged as dominant "tolerogenic" regulators of T cells because their deficiency results in severe autoimmune diseases. Cbl-b and Itch ligase activity regulate T-cell anergy and development of Foxp3+ regulatory T cells (Treg) in the periphery by modulating key components of T-cell receptor (TCR) and transforming growth factor-β (TGF-β) signaling. Manipulation of Cbl-b and Itch activities may provide unique opportunities to develop future therapies for immune disorders such as autoimmunity and cancer.

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Cbl-b and itch: Key regulators of peripheral T-cell tolerance

Abstract

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