CCAAT-enhancer binding protein: A component of a differentiation switch

Robert M. Umek, Alan D. Friedman, Steven L. Mcknight

Research output: Contribution to journalArticle

554 Scopus citations

Abstract

The CCAAT-enhancer binding protein (C/EBP) has now been found to promote the terminal differentiation of adipocytes. During the normal course of adipogenesis, C/EBP expression is restricted to a terminal phase wherein proliferative growth is arrested, and specialized cell phenotype is first manifested. A conditional form of C/EBP was developed, making it feasible to test its capacity to regulate the differentiation of cultured adipocytes. Premature expression of C/EBP in adipoblasts caused a direct cessation of mitotic growth. Moreover, when abetted by the effects of three adipogenic hormones, C/EBP promoted terminal cell differentiation. Since C/EBP is expressed in a variety of tissues, it may have a fundamental role in regulating the balance between cell growth and differentiation in higher animals.

Original languageEnglish (US)
Pages (from-to)288-292
Number of pages5
JournalScience
Volume251
Issue number4991
DOIs
StatePublished - Jan 1 1991

ASJC Scopus subject areas

  • General

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