CCAAT-enhancer binding protein

A component of a differentiation switch

Robert M. Umek, Alan D. Friedman, Steven L. Mcknight

Research output: Contribution to journalArticle

545 Citations (Scopus)

Abstract

The CCAAT-enhancer binding protein (C/EBP) has now been found to promote the terminal differentiation of adipocytes. During the normal course of adipogenesis, C/EBP expression is restricted to a terminal phase wherein proliferative growth is arrested, and specialized cell phenotype is first manifested. A conditional form of C/EBP was developed, making it feasible to test its capacity to regulate the differentiation of cultured adipocytes. Premature expression of C/EBP in adipoblasts caused a direct cessation of mitotic growth. Moreover, when abetted by the effects of three adipogenic hormones, C/EBP promoted terminal cell differentiation. Since C/EBP is expressed in a variety of tissues, it may have a fundamental role in regulating the balance between cell growth and differentiation in higher animals.

Original languageEnglish (US)
Pages (from-to)288-292
Number of pages5
JournalScience
Volume251
Issue number4991
StatePublished - Jan 18 1991

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CCAAT-Enhancer-Binding Proteins
Staphylococcal Protein A
Adipocytes
Cell Differentiation
Growth
Adipogenesis
Hormones
Phenotype

ASJC Scopus subject areas

  • General

Cite this

CCAAT-enhancer binding protein : A component of a differentiation switch. / Umek, Robert M.; Friedman, Alan D.; Mcknight, Steven L.

In: Science, Vol. 251, No. 4991, 18.01.1991, p. 288-292.

Research output: Contribution to journalArticle

Umek, RM, Friedman, AD & Mcknight, SL 1991, 'CCAAT-enhancer binding protein: A component of a differentiation switch', Science, vol. 251, no. 4991, pp. 288-292.
Umek, Robert M. ; Friedman, Alan D. ; Mcknight, Steven L. / CCAAT-enhancer binding protein : A component of a differentiation switch. In: Science. 1991 ; Vol. 251, No. 4991. pp. 288-292.
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