CD28-CD57+ T cells predominate in CD8 responses to glatiramer acetate

Robert B. Ratts; Amy E. Lovett-Racke; Judy Choy; Sara C. Northrop; Rehana Z. Hussain; Nitin J. Karandikar; Michael K. Racke

doi:10.1016/j.jneuroim.2006.06.001

CD28^-CD57⁺ T cells predominate in CD8 responses to glatiramer acetate

Robert B. Ratts, Amy E. Lovett-Racke, Judy Choy, Sara C. Northrop, Rehana Z. Hussain, Nitin J. Karandikar, Michael K. Racke

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

Human T cells adopt a CD28^-CD57⁺ phenotype in chronic viral infections and this has been hypothesized to result from continuous stimulation, however this phenotype may be due to direct viral effects on T cells. Employing MS patients before and after chronic in vivo administration of the antigen glatiramer acetate (GA) we examine this hypothesis. Pre-treatment glatiramer acetate-specific CD8 T cells were CD57^-Perforin^-. This changed to a predominantly CD28^-CD57⁺Perforin⁺ response after administration of this drug. This phenotype was only observed after chronic stimulation and not in a recall response to mumps. The relevance to GA's mechanism of action is discussed.

Original language	English (US)
Pages (from-to)	117-129
Number of pages	13
Journal	Journal of Neuroimmunology
Volume	178
Issue number	1-2
DOIs	https://doi.org/10.1016/j.jneuroim.2006.06.001
State	Published - Sep 2006

Keywords

Autoimmunity
Cell differentiation
Cytotoxic
Human
T cells
Viral

ASJC Scopus subject areas

Immunology and Allergy
Immunology
Neurology
Clinical Neurology

Access to Document

10.1016/j.jneuroim.2006.06.001

Cite this

@article{a775a47448404fe68bb02c59bc0cd1e6,

title = "CD28-CD57+ T cells predominate in CD8 responses to glatiramer acetate",

abstract = "Human T cells adopt a CD28-CD57+ phenotype in chronic viral infections and this has been hypothesized to result from continuous stimulation, however this phenotype may be due to direct viral effects on T cells. Employing MS patients before and after chronic in vivo administration of the antigen glatiramer acetate (GA) we examine this hypothesis. Pre-treatment glatiramer acetate-specific CD8 T cells were CD57-Perforin-. This changed to a predominantly CD28-CD57+Perforin+ response after administration of this drug. This phenotype was only observed after chronic stimulation and not in a recall response to mumps. The relevance to GA's mechanism of action is discussed.",

keywords = "Autoimmunity, Cell differentiation, Cytotoxic, Human, T cells, Viral",

author = "Ratts, {Robert B.} and Lovett-Racke, {Amy E.} and Judy Choy and Northrop, {Sara C.} and Hussain, {Rehana Z.} and Karandikar, {Nitin J.} and Racke, {Michael K.}",

note = "Funding Information: The authors thank Becky Price for performing the leukophereses. This study is supported by grants from the NIH NS-37513, NS-44250, AI-47133, National Multiple Sclerosis Society (NMSS) grant RG2969-B-7, a grant from the Yellow Rose Foundation (Dallas, Texas, USA) (M.K.R.), and NIH grant AI53439, (N.J.K). NJK and AELR are Harry Weaver Neuroscience Scholars of the National Multiple Sclerosis Society.",

year = "2006",

month = sep,

doi = "10.1016/j.jneuroim.2006.06.001",

language = "English (US)",

volume = "178",

pages = "117--129",

journal = "Journal of Neuroimmunology",

issn = "0165-5728",

publisher = "Elsevier",

number = "1-2",

}

TY - JOUR

T1 - CD28-CD57+ T cells predominate in CD8 responses to glatiramer acetate

AU - Ratts, Robert B.

AU - Lovett-Racke, Amy E.

AU - Choy, Judy

AU - Northrop, Sara C.

AU - Hussain, Rehana Z.

AU - Karandikar, Nitin J.

AU - Racke, Michael K.

N1 - Funding Information: The authors thank Becky Price for performing the leukophereses. This study is supported by grants from the NIH NS-37513, NS-44250, AI-47133, National Multiple Sclerosis Society (NMSS) grant RG2969-B-7, a grant from the Yellow Rose Foundation (Dallas, Texas, USA) (M.K.R.), and NIH grant AI53439, (N.J.K). NJK and AELR are Harry Weaver Neuroscience Scholars of the National Multiple Sclerosis Society.

PY - 2006/9

Y1 - 2006/9

N2 - Human T cells adopt a CD28-CD57+ phenotype in chronic viral infections and this has been hypothesized to result from continuous stimulation, however this phenotype may be due to direct viral effects on T cells. Employing MS patients before and after chronic in vivo administration of the antigen glatiramer acetate (GA) we examine this hypothesis. Pre-treatment glatiramer acetate-specific CD8 T cells were CD57-Perforin-. This changed to a predominantly CD28-CD57+Perforin+ response after administration of this drug. This phenotype was only observed after chronic stimulation and not in a recall response to mumps. The relevance to GA's mechanism of action is discussed.

AB - Human T cells adopt a CD28-CD57+ phenotype in chronic viral infections and this has been hypothesized to result from continuous stimulation, however this phenotype may be due to direct viral effects on T cells. Employing MS patients before and after chronic in vivo administration of the antigen glatiramer acetate (GA) we examine this hypothesis. Pre-treatment glatiramer acetate-specific CD8 T cells were CD57-Perforin-. This changed to a predominantly CD28-CD57+Perforin+ response after administration of this drug. This phenotype was only observed after chronic stimulation and not in a recall response to mumps. The relevance to GA's mechanism of action is discussed.

KW - Autoimmunity

KW - Cell differentiation

KW - Cytotoxic

KW - Human

KW - T cells

KW - Viral

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