CD28-CD57+ T cells predominate in CD8 responses to glatiramer acetate

Robert B. Ratts, Amy E. Lovett-Racke, Judy Choy, Sara C. Northrop, Rehana Z. Hussain, Nitin J. Karandikar, Michael K. Racke

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Human T cells adopt a CD28-CD57+ phenotype in chronic viral infections and this has been hypothesized to result from continuous stimulation, however this phenotype may be due to direct viral effects on T cells. Employing MS patients before and after chronic in vivo administration of the antigen glatiramer acetate (GA) we examine this hypothesis. Pre-treatment glatiramer acetate-specific CD8 T cells were CD57-Perforin-. This changed to a predominantly CD28-CD57+Perforin+ response after administration of this drug. This phenotype was only observed after chronic stimulation and not in a recall response to mumps. The relevance to GA's mechanism of action is discussed.

Original languageEnglish (US)
Pages (from-to)117-129
Number of pages13
JournalJournal of Neuroimmunology
Volume178
Issue number1-2
DOIs
StatePublished - Sep 2006

Fingerprint

Perforin
T-Lymphocytes
Phenotype
Mumps
Virus Diseases
Antigens
Pharmaceutical Preparations
Glatiramer Acetate
Therapeutics

Keywords

  • Autoimmunity
  • Cell differentiation
  • Cytotoxic
  • Human
  • T cells
  • Viral

ASJC Scopus subject areas

  • Immunology
  • Clinical Neurology
  • Immunology and Allergy
  • Neurology

Cite this

Ratts, R. B., Lovett-Racke, A. E., Choy, J., Northrop, S. C., Hussain, R. Z., Karandikar, N. J., & Racke, M. K. (2006). CD28-CD57+ T cells predominate in CD8 responses to glatiramer acetate. Journal of Neuroimmunology, 178(1-2), 117-129. https://doi.org/10.1016/j.jneuroim.2006.06.001

CD28-CD57+ T cells predominate in CD8 responses to glatiramer acetate. / Ratts, Robert B.; Lovett-Racke, Amy E.; Choy, Judy; Northrop, Sara C.; Hussain, Rehana Z.; Karandikar, Nitin J.; Racke, Michael K.

In: Journal of Neuroimmunology, Vol. 178, No. 1-2, 09.2006, p. 117-129.

Research output: Contribution to journalArticle

Ratts, RB, Lovett-Racke, AE, Choy, J, Northrop, SC, Hussain, RZ, Karandikar, NJ & Racke, MK 2006, 'CD28-CD57+ T cells predominate in CD8 responses to glatiramer acetate', Journal of Neuroimmunology, vol. 178, no. 1-2, pp. 117-129. https://doi.org/10.1016/j.jneuroim.2006.06.001
Ratts RB, Lovett-Racke AE, Choy J, Northrop SC, Hussain RZ, Karandikar NJ et al. CD28-CD57+ T cells predominate in CD8 responses to glatiramer acetate. Journal of Neuroimmunology. 2006 Sep;178(1-2):117-129. https://doi.org/10.1016/j.jneuroim.2006.06.001
Ratts, Robert B. ; Lovett-Racke, Amy E. ; Choy, Judy ; Northrop, Sara C. ; Hussain, Rehana Z. ; Karandikar, Nitin J. ; Racke, Michael K. / CD28-CD57+ T cells predominate in CD8 responses to glatiramer acetate. In: Journal of Neuroimmunology. 2006 ; Vol. 178, No. 1-2. pp. 117-129.
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