CD4+ CD25+ T cells prevent arthritis associated with Borrelia vaccination and infection

Dean T. Nardelli, Joseph P. Cloute, K. H Kevin Luk, Jose Torrealba, Thomas F. Warner, Steven M. Callister, Ronald F. Schell

Research output: Contribution to journalArticle

25 Scopus citations

Abstract

CD4+ CD25+ T cells are a population of regulatory T cells associated with control of arthritis in anti-interleukin-17 antibody-treated Borrelia-vaccinated and challenged gamma interferon-deficient mice. Here, we present direct evidence that adoptive transfer of enriched CD4+ CD25+ T cells from these mice can prevent the development of arthritis in Borrelia-vaccinated and challenged mice. These findings establish a major role for CD4+ CD25+ T cells in the prevention of arthritis in Borrelia-vaccinated and challenged animals.

Original languageEnglish (US)
Pages (from-to)786-792
Number of pages7
JournalClinical and Diagnostic Laboratory Immunology
Volume12
Issue number6
DOIs
Publication statusPublished - Jun 2005

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ASJC Scopus subject areas

  • Microbiology (medical)
  • Immunology and Allergy
  • Clinical Biochemistry
  • Immunology

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