CD56 reactivity in small cell carcinoma of the uterine cervix

Jorge Albores-Saavedra, Shahnila Latif, Kelley S. Carrick, Isabel Alvarado-Cabrero, Marjorie R. Fowler

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

Small cell carcinoma (SCC) of the uterine cervix, like its pulmonary counterpart, is a rare but distinctive neoplasm that should be separated from nonendocrine carcinomas because of its highly aggressive clinical course and response to chemotherapy and irradiation. CD56 (neural cell adhesion molecule) has recently been shown to be the best marker for the diagnosis of pulmonary SCC. In this study, we assessed the sensitivity and specificity of CD56 in the diagnosis of SCC of the uterine cervix compared with those of chromogranin and synaptophysin. Twenty-two (88%) of 25 SCCs of the uterine cervix labeled with CD56 in a predominantly membranous and diffuse pattern, whereas 16 of 25 (64%) stained with synaptophysin in a predominantly diffuse pattern and 8 of 25 (32%) showed predominantly focal immunoreactivity for chromogranin. In contrast, 3 of 21 (14%) moderately to poorly differentiated squamous cell carcinomas and 1 of 16 (6%) moderately differentiated adenocarcinomas showed focal immunoreactivity for CD56. Although not specific, CD56 seems to be the most sensitive marker for the diagnosis of SCC of the uterine cervix. Moreover, its diffuse reactivity reduces the possibility of obtaining negative results in small biopsy samples.

Original languageEnglish (US)
Pages (from-to)113-117
Number of pages5
JournalInternational Journal of Gynecological Pathology
Volume24
Issue number2
DOIs
StatePublished - Apr 2005

Fingerprint

Small Cell Carcinoma
Cervix Uteri
Chromogranins
Synaptophysin
Neural Cell Adhesion Molecules
Lung
Squamous Cell Carcinoma
Adenocarcinoma
Carcinoma
Biopsy
Drug Therapy
Sensitivity and Specificity
Neoplasms

Keywords

  • CD56
  • Chromogranin
  • Small cell carcinoma
  • Synaptophysin
  • Uterine cervix

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Obstetrics and Gynecology

Cite this

CD56 reactivity in small cell carcinoma of the uterine cervix. / Albores-Saavedra, Jorge; Latif, Shahnila; Carrick, Kelley S.; Alvarado-Cabrero, Isabel; Fowler, Marjorie R.

In: International Journal of Gynecological Pathology, Vol. 24, No. 2, 04.2005, p. 113-117.

Research output: Contribution to journalArticle

Albores-Saavedra, Jorge ; Latif, Shahnila ; Carrick, Kelley S. ; Alvarado-Cabrero, Isabel ; Fowler, Marjorie R. / CD56 reactivity in small cell carcinoma of the uterine cervix. In: International Journal of Gynecological Pathology. 2005 ; Vol. 24, No. 2. pp. 113-117.
@article{9cded4c8acc0492aa41d2a885416cc0a,
title = "CD56 reactivity in small cell carcinoma of the uterine cervix",
abstract = "Small cell carcinoma (SCC) of the uterine cervix, like its pulmonary counterpart, is a rare but distinctive neoplasm that should be separated from nonendocrine carcinomas because of its highly aggressive clinical course and response to chemotherapy and irradiation. CD56 (neural cell adhesion molecule) has recently been shown to be the best marker for the diagnosis of pulmonary SCC. In this study, we assessed the sensitivity and specificity of CD56 in the diagnosis of SCC of the uterine cervix compared with those of chromogranin and synaptophysin. Twenty-two (88{\%}) of 25 SCCs of the uterine cervix labeled with CD56 in a predominantly membranous and diffuse pattern, whereas 16 of 25 (64{\%}) stained with synaptophysin in a predominantly diffuse pattern and 8 of 25 (32{\%}) showed predominantly focal immunoreactivity for chromogranin. In contrast, 3 of 21 (14{\%}) moderately to poorly differentiated squamous cell carcinomas and 1 of 16 (6{\%}) moderately differentiated adenocarcinomas showed focal immunoreactivity for CD56. Although not specific, CD56 seems to be the most sensitive marker for the diagnosis of SCC of the uterine cervix. Moreover, its diffuse reactivity reduces the possibility of obtaining negative results in small biopsy samples.",
keywords = "CD56, Chromogranin, Small cell carcinoma, Synaptophysin, Uterine cervix",
author = "Jorge Albores-Saavedra and Shahnila Latif and Carrick, {Kelley S.} and Isabel Alvarado-Cabrero and Fowler, {Marjorie R.}",
year = "2005",
month = "4",
doi = "10.1097/00004347-200504000-00001",
language = "English (US)",
volume = "24",
pages = "113--117",
journal = "International Journal of Gynecological Pathology",
issn = "0277-1691",
publisher = "Lippincott Williams and Wilkins",
number = "2",

}

TY - JOUR

T1 - CD56 reactivity in small cell carcinoma of the uterine cervix

AU - Albores-Saavedra, Jorge

AU - Latif, Shahnila

AU - Carrick, Kelley S.

AU - Alvarado-Cabrero, Isabel

AU - Fowler, Marjorie R.

PY - 2005/4

Y1 - 2005/4

N2 - Small cell carcinoma (SCC) of the uterine cervix, like its pulmonary counterpart, is a rare but distinctive neoplasm that should be separated from nonendocrine carcinomas because of its highly aggressive clinical course and response to chemotherapy and irradiation. CD56 (neural cell adhesion molecule) has recently been shown to be the best marker for the diagnosis of pulmonary SCC. In this study, we assessed the sensitivity and specificity of CD56 in the diagnosis of SCC of the uterine cervix compared with those of chromogranin and synaptophysin. Twenty-two (88%) of 25 SCCs of the uterine cervix labeled with CD56 in a predominantly membranous and diffuse pattern, whereas 16 of 25 (64%) stained with synaptophysin in a predominantly diffuse pattern and 8 of 25 (32%) showed predominantly focal immunoreactivity for chromogranin. In contrast, 3 of 21 (14%) moderately to poorly differentiated squamous cell carcinomas and 1 of 16 (6%) moderately differentiated adenocarcinomas showed focal immunoreactivity for CD56. Although not specific, CD56 seems to be the most sensitive marker for the diagnosis of SCC of the uterine cervix. Moreover, its diffuse reactivity reduces the possibility of obtaining negative results in small biopsy samples.

AB - Small cell carcinoma (SCC) of the uterine cervix, like its pulmonary counterpart, is a rare but distinctive neoplasm that should be separated from nonendocrine carcinomas because of its highly aggressive clinical course and response to chemotherapy and irradiation. CD56 (neural cell adhesion molecule) has recently been shown to be the best marker for the diagnosis of pulmonary SCC. In this study, we assessed the sensitivity and specificity of CD56 in the diagnosis of SCC of the uterine cervix compared with those of chromogranin and synaptophysin. Twenty-two (88%) of 25 SCCs of the uterine cervix labeled with CD56 in a predominantly membranous and diffuse pattern, whereas 16 of 25 (64%) stained with synaptophysin in a predominantly diffuse pattern and 8 of 25 (32%) showed predominantly focal immunoreactivity for chromogranin. In contrast, 3 of 21 (14%) moderately to poorly differentiated squamous cell carcinomas and 1 of 16 (6%) moderately differentiated adenocarcinomas showed focal immunoreactivity for CD56. Although not specific, CD56 seems to be the most sensitive marker for the diagnosis of SCC of the uterine cervix. Moreover, its diffuse reactivity reduces the possibility of obtaining negative results in small biopsy samples.

KW - CD56

KW - Chromogranin

KW - Small cell carcinoma

KW - Synaptophysin

KW - Uterine cervix

UR - http://www.scopus.com/inward/record.url?scp=15244348397&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=15244348397&partnerID=8YFLogxK

U2 - 10.1097/00004347-200504000-00001

DO - 10.1097/00004347-200504000-00001

M3 - Article

C2 - 15782066

AN - SCOPUS:15244348397

VL - 24

SP - 113

EP - 117

JO - International Journal of Gynecological Pathology

JF - International Journal of Gynecological Pathology

SN - 0277-1691

IS - 2

ER -