CD8+ T cell help is required for efficient induction of EAE in Lewis rats

Monika Camara, Niklas Beyersdorf, Henrike J. Fischer, Marco J. Herold, Chi Wang Ip, Jens van den Brandt, Klaus V. Toyka, Joel D. Taurog, Thomas Hünig, Thomas Herrmann, Holger M. Reichardt, Andreas Weishaupt, Thomas Kerkau

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10 Scopus citations

Abstract

The role of CD8+ T cells in multiple sclerosis (MS) and experimental autoimmune encephalomyelitis (EAE) is still unclear. We describe here significantly reduced disease activity of EAE both in Lewis rats depleted of CD8+ T cells by monoclonal antibodies and CD8 knockout rats, which was accompanied by reduced leukocyte infiltration into the spinal cord. We detected myelin basic protein (MBP)-specific CD4+ T cells in peripheral lymphoid organs of CD8-depleted animals which, however, failed to differentiate into interferon-γ-producing effector cells. Our results indicate that CD8+ T cells interact with myelin-specific CD4+ T cells early in EAE enabling them to differentiate into pathogenic effector cells.

Original languageEnglish (US)
Pages (from-to)17-27
Number of pages11
JournalJournal of Neuroimmunology
Volume260
Issue number1-2
DOIs
StatePublished - May 8 2013

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Keywords

  • CD8 T cell
  • Experimental autoimmune encephalomyelitis
  • Multiple sclerosis

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Neurology
  • Clinical Neurology

Cite this

Camara, M., Beyersdorf, N., Fischer, H. J., Herold, M. J., Ip, C. W., van den Brandt, J., Toyka, K. V., Taurog, J. D., Hünig, T., Herrmann, T., Reichardt, H. M., Weishaupt, A., & Kerkau, T. (2013). CD8+ T cell help is required for efficient induction of EAE in Lewis rats. Journal of Neuroimmunology, 260(1-2), 17-27. https://doi.org/10.1016/j.jneuroim.2013.04.014