Abstract
The role of CD8+ T cells in multiple sclerosis (MS) and experimental autoimmune encephalomyelitis (EAE) is still unclear. We describe here significantly reduced disease activity of EAE both in Lewis rats depleted of CD8+ T cells by monoclonal antibodies and CD8 knockout rats, which was accompanied by reduced leukocyte infiltration into the spinal cord. We detected myelin basic protein (MBP)-specific CD4+ T cells in peripheral lymphoid organs of CD8-depleted animals which, however, failed to differentiate into interferon-γ-producing effector cells. Our results indicate that CD8+ T cells interact with myelin-specific CD4+ T cells early in EAE enabling them to differentiate into pathogenic effector cells.
Original language | English (US) |
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Pages (from-to) | 17-27 |
Number of pages | 11 |
Journal | Journal of Neuroimmunology |
Volume | 260 |
Issue number | 1-2 |
DOIs | |
State | Published - 2013 |
Keywords
- CD8 T cell
- Experimental autoimmune encephalomyelitis
- Multiple sclerosis
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology
- Neurology
- Clinical Neurology